# HISTORY 04 Aug 2016: Updated by: TOUCHUP-v1.21 # molecular_function 20160502: Bilateria_PTN000666004 has function serine-type peptidase activity (GO:0008236) 20160502: Mammalia_PTN000666006 has function sodium channel regulator activity (GO:0017080) # cellular_component 20160502: Bilateria_PTN000666004 is found in extrinsic component of plasma membrane (GO:0019897) 20160502: Bilateria_PTN000666004 is found in anchored component of plasma membrane (GO:0046658) # biological_process 20160502: Boreoeutheria_PTN000666008 participates in positive regulation of sodium ion transport (GO:0010765) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).