# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 18 Mar 2016: Updated by: TOUCHUP-v1.14 27 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150330: node_PTN000664502 has function adrenergic receptor activity (GO:0004935) 20150331: Euteleostomi_PTN000664647 has function epinephrine binding (GO:0051379) 20150330: Euteleostomi_PTN000664647 has function beta2-adrenergic receptor activity (GO:0004941) 20150331: Euteleostomi_PTN000664675 has function epinephrine binding (GO:0051379) 20150330: Euteleostomi_PTN000664675 has function beta3-adrenergic receptor activity (GO:0015052) 20150331: Euteleostomi_PTN000664675 has function norepinephrine binding (GO:0051380) 20150331: Euteleostomi_PTN001545429 has function epinephrine binding (GO:0051379) 20150331: Euteleostomi_PTN001545429 has function norepinephrine binding (GO:0051380) 20150330: Euteleostomi_PTN001545429 has function beta1-adrenergic receptor activity (GO:0004940) 20150330: Bilateria_PTN001545550 has function alpha1-adrenergic receptor activity (GO:0004937) 20150330: Deuterostomia_PTN001545415 has function dopamine neurotransmitter receptor activity, coupled via Gi/Go (GO:0001591) 20150330: Deuterostomia_PTN001545415 has function dopamine binding (GO:0035240) 20150330: Euteleostomi_PTN001205270 has LOST/MODIFIED function adrenergic receptor activity (GO:0004935) 20150330: Sus scrofa_I3LFJ1 has LOST/MODIFIED function adrenergic receptor activity (GO:0004935) 20150330: Deuterostomia_PTN001545415 has LOST/MODIFIED function adrenergic receptor activity (GO:0004935) # cellular_component 20150330: node_PTN000664502 is found in integral component of plasma membrane (GO:0005887) 20150330: Deuterostomia_PTN001545415 is found in synaptic vesicle membrane (GO:0030672) # biological_process 20150331: Eumetazoa_PTN001205212 participates in adenylate cyclase-activating adrenergic receptor signaling pathway (GO:0071880) 20150330: node_PTN000664502 participates in cell-cell signaling (GO:0007267) 20150330: Euteleostomi_PTN000664647 participates in vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure (GO:0002025) 20150331: Euteleostomi_PTN000664647 participates in negative regulation of smooth muscle contraction (GO:0045986) 20150330: Euteleostomi_PTN000664675 participates in vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure (GO:0002025) 20150331: Euteleostomi_PTN000664675 participates in temperature homeostasis (GO:0001659) 20150330: Euteleostomi_PTN001545429 participates in vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure (GO:0002025) 20150331: Euteleostomi_PTN001545429 participates in positive regulation of heart rate by epinephrine-norepinephrine (GO:0001996) 20150331: Euteleostomi_PTN001545429 participates in temperature homeostasis (GO:0001659) 20150331: Bilateria_PTN001545550 participates in positive regulation of smooth muscle contraction (GO:0045987) 20150331: Bilateria_PTN001545550 participates in norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure (GO:0001994) 20150331: Bilateria_PTN001545550 participates in positive regulation of vasoconstriction (GO:0045907) 20150331: Bilateria_PTN001545550 participates in phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200) 20150331: Bilateria_PTN001545550 participates in positive regulation of cytosolic calcium ion concentration (GO:0007204) 20150331: Euteleostomi_PTN000664586 participates in glucose homeostasis (GO:0042593) 20150331: Deuterostomia_PTN001545415 participates in response to toxic substance (GO:0009636) 20150331: Deuterostomia_PTN001545415 participates in negative regulation of cytosolic calcium ion concentration (GO:0051481) 20150330: Deuterostomia_PTN001545415 participates in negative regulation of synaptic transmission, glutamatergic (GO:0051967) 20150330: Deuterostomia_PTN001545415 participates in negative regulation of voltage-gated calcium channel activity (GO:1901386) 20150330: Deuterostomia_PTN001545415 participates in negative regulation of adenylate cyclase activity (GO:0007194) 20150330: Deuterostomia_PTN001545415 participates in synaptic transmission, dopaminergic (GO:0001963) 20150330: Deuterostomia_PTN001545415 participates in response to drug (GO:0042493) 20150331: Deuterostomia_PTN001545415 participates in behavioral response to ethanol (GO:0048149) 20150331: Deuterostomia_PTN001545415 participates in behavioral response to cocaine (GO:0048148) 20150330: Deuterostomia_PTN001545415 participates in regulation of potassium ion transport (GO:0043266) 20150330: Deuterostomia_PTN001545415 participates in regulation of dopamine secretion (GO:0014059) 20150330: Deuterostomia_PTN001545415 participates in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway (GO:0051482) 20150330: Deuterostomia_PTN001545415 participates in adenylate cyclase-inhibiting dopamine receptor signaling pathway (GO:0007195) 20150330: Deuterostomia_PTN001545415 participates in phospholipase C-activating dopamine receptor signaling pathway (GO:0060158) 20150331: Deuterostomia_PTN001545415 does NOT participate in adenylate cyclase-activating adrenergic receptor signaling pathway (GO:0071880) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES References DRD2 receptor: http://www.ncbi.nlm.nih.gov/books/NBK27980/ Adrenergic receptors: http://www.uky.edu/~mtp/OBI836AR.html Annotated PG & MAF 2015-03-31 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).