# HISTORY 24 Jun 2016: Saved by mfeuerma using Paint 2.0-beta19 # molecular_function 20160623: Eumetazoa_PTN001204971 has function G-protein coupled receptor activity (GO:0004930) 20160623: Bilateria_PTN000664208 has function serotonin binding (GO:0051378) 20160623: Bilateria_PTN000664208 has function G-protein coupled serotonin receptor activity (GO:0004993) 20160623: Bilateria_PTN001955878 has function G-protein coupled serotonin receptor activity (GO:0004993) 20160623: Bilateria_PTN001955878 has function serotonin binding (GO:0051378) 20160623: Ecdysozoa_PTN000664482 has function octopamine receptor activity (GO:0004989) 20160623: Deuterostomia_PTN001955842 has function G-protein coupled serotonin receptor activity (GO:0004993) 20160623: node_PTN000664111 has function G-protein coupled serotonin receptor activity (GO:0004993) 20160623: node_PTN000664111 has function neurotransmitter receptor activity (GO:0030594) # cellular_component 20160623: Eumetazoa_PTN001204971 is found in integral component of plasma membrane (GO:0005887) 20160623: Eumetazoa_PTN001204971 is found in dendrite (GO:0030425) # biological_process 20160623: Bilateria_PTN001955878 participates in adenylate cyclase-inhibiting serotonin receptor signaling pathway (GO:0007198) 20160623: Bilateria_PTN000664208 participates in adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193) 20160623: Ecdysozoa_PTN000664201 participates in octopamine signaling pathway (GO:0071927) 20160623: Eumetazoa_PTN001204971 participates in G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187) 20160623: Bilateria_PTN000664387 participates in adenylate cyclase-activating serotonin receptor signaling pathway (GO:0007192) 20160623: Eumetazoa_PTN001204971 participates in chemical synaptic transmission (GO:0007268) 20160623: Euteleostomi_PTN000664141 participates in phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200) 20160623: node_PTN000664115 participates in release of sequestered calcium ion into cytosol (GO:0051209) 20160623: node_PTN000664115 participates in phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200) 20160624: node_PTN000664115 participates in response to drug (GO:0042493) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).