# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 18 Mar 2016: Updated by: TOUCHUP-v1.14 27 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20140923: Eumetazoa_PTN001202348 has function G-protein coupled receptor activity (GO:0004930) 20140923: Eumetazoa_PTN001202348 has function peptide binding (GO:0042277) 20140923: Bilateria_PTN001202415 has function vasopressin receptor activity (GO:0005000) 20140923: Euteleostomi_PTN000662656 has function oxytocin receptor activity (GO:0004990) 20140923: Chordata_PTN001202518 has function fatty acid binding (GO:0005504) 20140923: Chordata_PTN001202518 has function taste receptor activity (GO:0008527) 20140923: Chordata_PTN001202351 has function gonadotropin-releasing hormone receptor activity (GO:0004968) 20140923: Pancrustacea_PTN001202404 has function adipokinetic hormone receptor activity (GO:0097003) 20140923: Chordata_PTN001544301 has function neuropeptide receptor activity (GO:0008188) 20140923: Euteleostomi_PTN000662461 has function orexin receptor activity (GO:0016499) 20140923: Euteleostomi_PTN000662355 has function cholecystokinin receptor activity (GO:0004951) 20140923: Chordata_PTN001202518 has LOST/MODIFIED function peptide binding (GO:0042277) # cellular_component 20140923: Eumetazoa_PTN001202348 is found in integral component of plasma membrane (GO:0005887) # biological_process 20140923: Eumetazoa_PTN001202348 participates in cellular response to hormone stimulus (GO:0032870) 20140923: Eumetazoa_PTN001202348 participates in response to peptide (GO:1901652) 20140923: node_PTN000662574 participates in positive regulation of vasoconstriction (GO:0045907) 20140923: node_PTN000662574 participates in regulation of systemic arterial blood pressure by vasopressin (GO:0001992) 20140924: Theria _PTN000662711 participates in maternal behavior (GO:0042711) 20140924: Theria _PTN000662660 participates in social behavior (GO:0035176) 20140924: Theria _PTN000662660 participates in lactation (GO:0007595) 20140924: Theria _PTN000662660 participates in female pregnancy (GO:0007565) 20140924: Theria _PTN000662660 participates in maternal behavior (GO:0042711) 20140923: Chordata_PTN001202518 participates in hormone secretion (GO:0046879) 20140923: Chordata_PTN001202351 participates in cellular response to gonadotropin-releasing hormone (GO:0097211) 20140923: Chordata_PTN001544301 participates in synaptic transmission (GO:0007268) 20140923: Euteleostomi_PTN000662461 participates in feeding behavior (GO:0007631) 20140923: Euteleostomi_PTN000662461 participates in regulation of circadian sleep/wake cycle, sleep (GO:0045187) 20140923: Euteleostomi_PTN000662355 participates in regulation of hormone secretion (GO:0046883) 20140923: Euteleostomi_PTN000662355 participates in cholecystokinin signaling pathway (GO:0038188) 20140923: Euteleostomi_PTN000662355 participates in digestion (GO:0007586) 20140923: Euteleostomi_PTN000662355 participates in feeding behavior (GO:0007631) 20140923: Chordata_PTN001202518 does NOT participate in cellular response to hormone stimulus (GO:0032870) 20140923: Chordata_PTN001202518 does NOT participate in response to peptide (GO:1901652) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES - Not familiar enough with GPCR to annotation downstream pathways. - Annotated by PG and VH. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).