# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 18 Mar 2016: Updated by: TOUCHUP-v1.14 27 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150605: root_PTN000660491 has function G-protein coupled peptide receptor activity (GO:0008528) 20150605: Chordata_PTN001201102 has function leukotriene B4 receptor activity (GO:0001632) 20150605: Arthropoda_PTN001954962 has function corazonin receptor activity (GO:0035237) 20150605: Deuterostomia_PTN001201163 has function urotensin II receptor activity (GO:0001604) 20150605: Deuterostomia_PTN001954973 has function cysteinyl leukotriene receptor activity (GO:0001631) 20150605: Deuterostomia_PTN001954983 has function galanin receptor activity (GO:0004966) 20150605: Ecdysozoa_PTN001543489 has function allatostatin receptor activity (GO:0008261) # cellular_component 20150605: root_PTN000660491 is found in integral component of plasma membrane (GO:0005887) # biological_process 20150605: root_PTN000660491 participates in phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200) 20150605: root_PTN000660491 participates in neuropeptide signaling pathway (GO:0007218) 20150605: Chordata_PTN001201102 participates in inflammatory response (GO:0006954) 20150605: Mammalia_PTN000660265 participates in circulatory system process (GO:0003013) 20150605: Mammalia_PTN001954979 participates in circulatory system process (GO:0003013) 20150605: Deuterostomia_PTN001954983 participates in adenylate cyclase-modulating G-protein coupled receptor signaling pathway (GO:0007188) 20150605: Euteleostomi_PTN000660323 does NOT participate in phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES Annotated to phospholipase C-activating G-protein coupled receptor signaling pathway to the root, since there is a lot of evidence throughout the tree. Added a 'NOT annotation to the GALR1 node (PTN000660323) based on PMID:17143559 and PMID:25428932. PG 2015-06-05 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).