# HISTORY 28 Nov 2016: Saved by mfeuerma using Paint 2.28 on 28 Nov 2016 using PANTHER version UPL 11.0 # molecular_function 20161128: root_PTN000657997 has function transporter activity (GO:0005215) 20161128: Mammalia_PTN001200526 has function purine nucleotide transmembrane transporter activity (GO:0015216) 20161128: Mammalia_PTN001200526 has function organic anion transmembrane transporter activity (GO:0008514) 20161128: root_PTN000657997 has function ATPase activity, coupled to transmembrane movement of substances (GO:0042626) 20161128: node_PTN001200541 contributes to function potassium channel activity (GO:0005267) 20161128: Euteleostomi_PTN000658664 has function chloride channel activity (GO:0005254) 20161128: Euteleostomi_PTN000658664 has function ATP-binding and phosphorylation-dependent chloride channel activity (GO:0005224) 20161128: Mammalia_PTN000658334 has function drug transmembrane transporter activity (GO:0015238) 20161128: Mammalia_PTN000658334 has function xenobiotic-transporting ATPase activity (GO:0008559) 20161128: Mammalia_PTN000658334 has function organic anion transmembrane transporter activity (GO:0008514) 20161128: Fungi_PTN001200388 has function peptide-transporting ATPase activity (GO:0015440) 20161128: Saccharomycetales_PTN001200390 has function bilirubin transmembrane transporter activity (GO:0015127) 20161128: Saccharomycetales_PTN001954317 has function xenobiotic-transporting ATPase activity (GO:0008559) 20161128: Eutheria_PTN000658336 has function glutathione S-conjugate-exporting ATPase activity (GO:0015431) 20161128: Eutheria_PTN000658336 has function glutathione transmembrane transporter activity (GO:0034634) # cellular_component 20161128: Viridiplantae_PTN000658555 is found in vacuolar membrane (GO:0005774) 20161128: Dikarya_PTN001200389 is found in fungal-type vacuole membrane (GO:0000329) 20161128: Eukaryota_PTN001954664 is found in vacuolar membrane (GO:0005774) 20161128: Eukaryota_PTN000658000 is found in integral component of plasma membrane (GO:0005887) 20161128: Tetrapoda_PTN000658318 is found in basolateral plasma membrane (GO:0016323) 20161128: Euteleostomi_PTN000658664 is found in apical plasma membrane (GO:0016324) 20161128: Eukaryota_PTN002384094 is found in integral component of plasma membrane (GO:0005887) 20161128: root_PTN000657997 is found in membrane (GO:0016020) 20161128: Viridiplantae_PTN000658555 is found in plant-type vacuole (GO:0000325) 20161128: Deuterostomia_PTN002384279 is found in plasma membrane (GO:0005886) 20161128: node_PTN002384214 is found in plant-type vacuole (GO:0000325) 20161128: Dikarya_PTN002384084 is found in fungal-type vacuole (GO:0000324) 20161128: Saccharomycetales_PTN001954317 is NOT found in fungal-type vacuole (GO:0000324) 20161128: Saccharomycetales_PTN001954317 is found in plasma membrane (GO:0005886) 20161128: Dikarya_PTN002384084 is found in fungal-type vacuole membrane (GO:0000329) 20161128: Saccharomycetales_PTN001954317 is NOT found in fungal-type vacuole membrane (GO:0000329) 20161128: Tetrapoda_PTN002384111 is found in apical plasma membrane (GO:0016324) 20161128: node_PTN001200541 is found in sarcolemma (GO:0042383) 20161128: node_PTN001200541 is found in voltage-gated potassium channel complex (GO:0008076) 20161128: node_PTN001200541 is found in ATP-sensitive potassium channel complex (GO:0008282) 20161128: Euteleostomi_PTN000658664 is found in cytosol (GO:0005829) 20161128: Mammalia_PTN001200526 is found in integral component of plasma membrane (GO:0005887) 20161128: Ascomycota_PTN000658404 is found in fungal-type vacuole (GO:0000324) 20161128: node_PTN000658434 is NOT found in integral component of plasma membrane (GO:0005887) 20161128: Ascomycota_PTN000658404 is found in vacuolar membrane (GO:0005774) # biological_process 20161128: Mammalia_PTN001200526 participates in organic anion transport (GO:0015711) 20161128: root_PTN000657997 participates in transmembrane transport (GO:0055085) 20161128: Dikarya_PTN002384084 participates in organic anion transport (GO:0015711) 20161128: node_PTN001954424 participates in sorocarp morphogenesis (GO:0031288) 20161128: Tetrapoda_PTN002384111 participates in cellular response to hormone stimulus (GO:0032870) 20161128: node_PTN001200541 participates in potassium ion transport (GO:0006813) 20161128: node_PTN001200541 participates in response to drug (GO:0042493) 20161128: Euteleostomi_PTN000658664 participates in chloride transport (GO:0006821) 20161128: Euteleostomi_PTN000658664 participates in chloride transmembrane transport (GO:1902476) 20161128: Euteleostomi_PTN000658664 participates in bicarbonate transport (GO:0015701) 20161128: Mammalia_PTN000658334 participates in xenobiotic transport (GO:0042908) 20161128: Eutheria_PTN000658336 participates in glutathione transmembrane transport (GO:0034775) 20161128: Mammalia_PTN000658334 participates in drug transmembrane transport (GO:0006855) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).