# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 18 Mar 2016: Updated by: TOUCHUP-v1.14 27 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20141210: Eumetazoa_PTN001193216 has function chromatin binding (GO:0003682) 20141210: Eumetazoa_PTN001193216 has function RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 20141210: Eumetazoa_PTN001193216 has function RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) # cellular_component 20141210: Eumetazoa_PTN001193216 is found in I-kappaB/NF-kappaB complex (GO:0033256) 20141210: Eumetazoa_PTN001193216 is found in cytosol (GO:0005829) # biological_process 20141210: Eumetazoa_PTN001193216 participates in positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 20141210: Eumetazoa_PTN001193216 participates in I-kappaB kinase/NF-kappaB signaling (GO:0007249) 20141210: Eumetazoa_PTN001193216 participates in NIK/NF-kappaB signaling (GO:0038061) 20141210: Eumetazoa_PTN001193216 participates in inflammatory response (GO:0006954) 20141210: Eumetazoa_PTN001193216 participates in response to cytokine (GO:0034097) 20141210: Eumetazoa_PTN001193216 participates in innate immune response (GO:0045087) 20141210: Eumetazoa_PTN001193216 participates in negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 20141210: Arthropoda_PTN001193253 does NOT participate in inflammatory response (GO:0006954) 20141210: Arthropoda_PTN001539226 does NOT participate in inflammatory response (GO:0006954) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).