# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 18 Mar 2016: Updated by: TOUCHUP-v1.14 27 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20140529: root_PTN000648413 has function ATPase activity (GO:0016887) 20140529: root_PTN000648413 has function microtubule motor activity (GO:0003777) 20140529: node_PTN001190049 has function ATP-dependent microtubule motor activity, plus-end-directed (GO:0008574) 20140529: Eukaryota_PTN000648414 has function ATP-dependent microtubule motor activity, plus-end-directed (GO:0008574) 20140529: Eukaryota_PTN000649234 has function ATP-dependent microtubule motor activity, plus-end-directed (GO:0008574) 20140529: Saccharomycetaceae_PTN000649257 has function ATP-dependent microtubule motor activity, minus-end-directed (GO:0008569) 20140529: Embryophyta_PTN001189791 has function ATP-dependent microtubule motor activity, plus-end-directed (GO:0008574) 20140529: Eukaryota_PTN001537455 has function ATP-dependent microtubule motor activity, plus-end-directed (GO:0008574) 20140529: Eumetazoa_PTN001189922 has function ATP-dependent microtubule motor activity, plus-end-directed (GO:0008574) # cellular_component 20140529: root_PTN000648413 is found in kinesin complex (GO:0005871) # biological_process 20140530: root_PTN000648413 participates in microtubule-based movement (GO:0007018) 20140709: Eukaryota_PTN000649974 participates in microtubule depolymerization (GO:0007019) 20140709: Eukaryota_PTN000649974 participates in mitotic sister chromatid segregation (GO:0000070) 20140709: Eukaryota_PTN000648414 participates in protein localization (GO:0008104) 20140709: Eukaryota_PTN000648414 participates in cytoskeleton-dependent intracellular transport (GO:0030705) 20140709: Opisthokonta_PTN001189978 participates in axon guidance (GO:0007411) 20140709: Eukaryota_PTN000649235 participates in mitotic spindle assembly (GO:0090307) 20140709: Eukaryota_PTN000649235 participates in chromosome segregation (GO:0007059) 20140709: Eumetazoa_PTN001190402 participates in cilium morphogenesis (GO:0060271) 20140709: Eumetazoa_PTN001190402 participates in neurogenesis (GO:0022008) 20140709: Eumetazoa_PTN001189481 participates in mitotic spindle midzone assembly (GO:0051256) 20140709: Eumetazoa_PTN001189922 participates in neurogenesis (GO:0022008) 20140709: Eumetazoa_PTN001189922 participates in cell projection organization (GO:0030030) 20140709: Eumetazoa_PTN001190381 participates in cytoskeleton-dependent intracellular transport (GO:0030705) 20140709: Eukaryota_PTN000649840 does NOT participate in mitotic cell cycle (GO:0000278) 20140709: Eukaryota_PTN000648522 participates in cytoskeleton-dependent intracellular transport (GO:0030705) 20140709: Euteleostomi_PTN000716759 participates in intracellular protein transport (GO:0006886) 20140709: Euteleostomi_PTN000648630 participates in vesicle-mediated transport (GO:0016192) 20140530: Bilateria_PTN000649056 does NOT participate in microtubule-based movement (GO:0007018) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES PTHR24115 Big family http://en.wikipedia.org/wiki/Kinesin A kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule filaments, and are powered by the hydrolysis of ATP (thus kinesins are ATPases). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cellular cargo, such as in axonal transport. Most kinesins walk towards the plus end of a microtubule, which, in most cells, entails transporting cargo from the centre of the cell towards the periphery. This form of transport is known as anterograde transport. In contrast, dyneins are motor proteins that move toward the microtubules' minus end. motor proteins that transport organelles and protein complexes in a microtubule- and ATP-dependent manner. Saccharomyces cerevisiae has the fewest kinesin genes, 6, and flowering plants have the most: 61 in Arabidopsis and 41 in rice. The mitotic kinesins in the BIMC/Kinesin-5 and the NCD/Kinesin-14 subfamilies appear to be similar to those in fungi and animals Kinesins are grouped into more than a dozen subfamilies by phylogenetic analyses of their motor domains (Schoch et al., 2003; Dagenbach and Endow, 2004). A recent effort by the kinesin research community has introduced a new nomenclature system to name established kinesin subfamilies from Kinesin-1 to Kinesin-14 (Lawrence et al., 2004). PMID:16084724 Analysis of the kinesin superfamily: insights into structure and function. PMID:15479732 A standardized kinesin nomenclature. Put �not� in node PTN000649056 according to: PMID:19914172 Amino acid comparisons demonstrated that motifs ��IFAYGQT��, essential for ATPase activity of KIFs, was not conserved in the KIF26A motor domain According to MSA, motifs ��IFAYGQT�� was not conserved in node PTN000649056 LN 7/18/2014 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).