# HISTORY 27 Mar 2016: Updated by: TOUCHUP-v1.15 18 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component 20140710: Eukaryota_PTN000645840 is found in centrosome (GO:0005813) 20140710: Eukaryota_PTN000645840 is found in intraciliary transport particle B (GO:0030992) 20140710: Eukaryota_PTN000645840 is found in cilium (GO:0005929) 20140710: Viridiplantae_PTN000645866 is NOT found in centrosome (GO:0005813) # biological_process 20140710: Eukaryota_PTN000645840 participates in cilium assembly (GO:0042384) # PRUNED 27 Mar 2016: Viridiplantae_PTN001187025 has been pruned from tree # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES 18 Mar 2016: Viridiplantae_PTN001187025 has been pruned from tree This family contains IFT80, a subunit of the intraciliary transport complex IFT B. The IFT B complex is found in all types of cilia, both primary cilia and motile cilia and is involved in intraciliary anterograde transport (from the base to the tip) within the cilium (PMID:19253336, PMID:19450523, PMID:23945166). Comments on the tree ------------------ Pruned a node containing A. thaliana ROS4 and numerous other sequences because ROS4 is experimentally characterized to be a histone acetyltransferase, not a member of the IFT B complex, and the alignment of the sequences in this group look like they belong together, but not with the IFT80 sequences. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).