# HISTORY 17 Jan 2017: Saved by pgaudet using Paint v2.29 on 17 Jan 2017 using PANTHER version 16 Jan 2017: Saved by pgaudet using Paint v2.29 on 13 Jan 2017 using PANTHER version UPL 11.0 16 Jan 2017: Saved by pgaudet using Paint v2.29 on 16 Jan 2017 using PANTHER version # molecular_function 20170113: root_PTN000211803 has function transmembrane transporter activity (GO:0022857) 20170116: Eukaryota_PTN001942979 has function amino acid transmembrane transporter activity (GO:0015171) 20170116: Eukaryota_PTN002377726 has function acyl carnitine transmembrane transporter activity (GO:0015227) 20170113: Eukaryota_PTN000642030 has function pyrimidine nucleotide transmembrane transporter activity (GO:0015218) 20170113: Eukaryota_PTN001942724 has function ATP transmembrane transporter activity (GO:0005347) 20170113: Eukaryota_PTN001942724 has function ADP transmembrane transporter activity (GO:0015217) 20170113: Eukaryota_PTN001942724 has function NAD transporter activity (GO:0051724) 20170113: Eukaryota_PTN001942724 has function FAD transmembrane transporter activity (GO:0015230) 20170113: Eukaryota_PTN001942724 has function FMN transmembrane transporter activity (GO:0044610) 20170113: Eukaryota_PTN001942724 has function AMP transmembrane transporter activity (GO:0080122) 20170113: Eukaryota_PTN001942724 has function coenzyme A transmembrane transporter activity (GO:0015228) 20170113: Eukaryota_PTN000641105 has function coenzyme A transmembrane transporter activity (GO:0015228) 20170113: Eukaryota_PTN000641105 has function AMP transmembrane transporter activity (GO:0080122) 20170113: Eukaryota_PTN000641105 has function ADP transmembrane transporter activity (GO:0015217) 20170116: Eukaryota_PTN000641020 has function FAD transmembrane transporter activity (GO:0015230) 20170116: Eukaryota_PTN000641020 has function folic acid transporter activity (GO:0008517) 20170116: Eukaryota_PTN002377805 has function magnesium ion transmembrane transporter activity (GO:0015095) 20170116: Eukaryota_PTN001183594 has function NAD transporter activity (GO:0051724) 20170116: Eukaryota_PTN000756630 has function S-adenosyl-L-methionine transmembrane transporter activity (GO:0000095) 20170116: Eukaryota_PTN001942042 has function oxoglutarate:malate antiporter activity (GO:0015367) 20170116: Eukaryota_PTN000639943 has function phosphate ion transmembrane transporter activity (GO:0015114) 20170116: Eukaryota_PTN000641358 has function L-ornithine transmembrane transporter activity (GO:0000064) 20170116: Eukaryota_PTN001183940 has function dicarboxylic acid transmembrane transporter activity (GO:0005310) 20170116: Eukaryota_PTN000756618 has function antiporter activity (GO:0015297) 20170116: Eukaryota_PTN000756618 has function succinate transmembrane transporter activity (GO:0015141) 20170116: Eukaryota_PTN000756618 has function sulfate transmembrane transporter activity (GO:0015116) 20170116: Eukaryota_PTN000756618 has function phosphate transmembrane transporter activity (GO:1901677) 20170116: Eukaryota_PTN000756618 has function malate transmembrane transporter activity (GO:0015140) 20170116: Eukaryota_PTN000756618 has function oxaloacetate transmembrane transporter activity (GO:0015131) 20170116: Eukaryota_PTN000756618 has function thiosulfate transmembrane transporter activity (GO:0015117) 20170116: Eukaryota_PTN000640304 has function L-glutamate transmembrane transporter activity (GO:0005313) 20170116: Eukaryota_PTN001183044 has function high-affinity glutamate transmembrane transporter activity (GO:0005314) 20170113: Eukaryota_PTN001370848 has function structural constituent of ribosome (GO:0003735) 20170113: Eukaryota_PTN001370848 has LOST/MODIFIED function transmembrane transporter activity (GO:0022857) 20170116: Drosophila melanogaster_FBgn0031881 has LOST/MODIFIED function carnitine:acyl carnitine antiporter activity (GO:0005476) 20170116: Drosophila melanogaster_FBgn0031881 has LOST/MODIFIED function carnitine transmembrane transporter activity (GO:0015226) 20170116: Eukaryota_PTN002377942 has LOST/MODIFIED function L-ornithine transmembrane transporter activity (GO:0000064) 20170116: Eukaryota_PTN001184222 has LOST/MODIFIED function L-ornithine transmembrane transporter activity (GO:0000064) 20170117: Eukaryota_PTN000640306 has function L-aspartate transmembrane transporter activity (GO:0015183) 20170117: Eukaryota_PTN001183376 has function carnitine:acyl carnitine antiporter activity (GO:0005476) 20170117: Eukaryota_PTN001183376 has function carnitine transmembrane transporter activity (GO:0015226) 20170117: Euteleostomi_PTN000641524 has LOST/MODIFIED function carnitine transmembrane transporter activity (GO:0015226) 20170117: Euteleostomi_PTN000641524 has LOST/MODIFIED function carnitine:acyl carnitine antiporter activity (GO:0005476) 20170117: Eukaryota_PTN002378075 has function phosphate transmembrane transporter activity (GO:1901677) 20170117: Eukaryota_PTN000756668 has function thiamine transmembrane transporter activity (GO:0015234) 20170117: Eukaryota_PTN000642156 has function oxidative phosphorylation uncoupler activity (GO:0017077) 20170117: Viridiplantae_PTN000640278 has function ATP transmembrane transporter activity (GO:0005347) 20170117: Eukaryota_PTN000639904 has function glycine transmembrane transporter activity (GO:0015187) 20170117: Eukaryota_PTN000641807 has function iron ion transmembrane transporter activity (GO:0005381) 20170117: Eukaryota_PTN000640049 has function ATP:ADP antiporter activity (GO:0005471) 20170117: saccharomyceta_PTN001942222 has function tricarboxylate secondary active transmembrane transporter activity (GO:0005371) 20170117: Eumetazoa_PTN001182669 has function citrate transmembrane transporter activity (GO:0015137) 20170117: Eukaryota_PTN000640552 has function citrate transmembrane transporter activity (GO:0015137) 20170117: Eukaryota_PTN000641656 has function ATP transmembrane transporter activity (GO:0005347) 20170117: Eukaryota_PTN000641656 has function ADP transmembrane transporter activity (GO:0015217) 20170117: Eukaryota_PTN000642145 has function guanine nucleotide transmembrane transporter activity (GO:0001409) # cellular_component 20170113: root_PTN000211803 is found in integral component of membrane (GO:0016021) 20170113: Eukaryota_PTN001183376 is found in mitochondrial inner membrane (GO:0005743) 20170113: Eukaryota_PTN001942979 is found in mitochondrion (GO:0005739) 20170116: Eukaryota_PTN000642030 is found in mitochondrial membrane (GO:0031966) 20170113: Eukaryota_PTN001942724 is found in integral component of peroxisomal membrane (GO:0005779) 20170116: Eukaryota_PTN001942541 is found in mitochondrion (GO:0005739) 20170116: Eukaryota_PTN000641105 is found in mitochondrial inner membrane (GO:0005743) 20170116: Eukaryota_PTN000641020 is found in mitochondrion (GO:0005739) 20170116: Eukaryota_PTN002377805 is found in mitochondrial inner membrane (GO:0005743) 20170116: Embryophyta_PTN001183722 is found in chloroplast envelope (GO:0009941) 20170116: Eukaryota_PTN001183594 is found in mitochondrion (GO:0005739) 20170116: Eukaryota_PTN002377827 is found in mitochondrial inner membrane (GO:0005743) 20170116: Viridiplantae_PTN000640522 is found in chloroplast envelope (GO:0009941) 20170116: Eukaryota_PTN001942042 is found in mitochondrial inner membrane (GO:0005743) 20170116: Eukaryota_PTN000639943 is found in mitochondrion (GO:0005739) 20170116: Eukaryota_PTN000641358 is found in mitochondrial inner membrane (GO:0005743) 20170116: Eukaryota_PTN001183940 is found in mitochondrial inner membrane (GO:0005743) 20170116: Eukaryota_PTN000756618 is found in mitochondrial inner membrane (GO:0005743) 20170116: Eukaryota_PTN000641934 is found in mitochondrion (GO:0005739) 20170116: Eukaryota_PTN000640304 is found in mitochondrial inner membrane (GO:0005743) 20170113: Eukaryota_PTN001941897 is found in peroxisome (GO:0005777) 20170113: Eukaryota_PTN001370848 is found in mitochondrial large ribosomal subunit (GO:0005762) 20170117: Eukaryota_PTN002378075 is found in integral component of mitochondrial inner membrane (GO:0031305) 20170117: Eukaryota_PTN000756668 is found in integral component of mitochondrial inner membrane (GO:0031305) 20170117: Eukaryota_PTN001942899 is found in mitochondrion (GO:0005739) 20170117: Eukaryota_PTN000642156 is found in mitochondrial inner membrane (GO:0005743) 20170117: node_PTN002378119 is found in mitochondrion (GO:0005739) 20170117: Viridiplantae_PTN000640278 is found in thylakoid membrane (GO:0042651) 20170117: Eukaryota_PTN000639904 is found in mitochondrion (GO:0005739) 20170117: Eukaryota_PTN000641807 is found in mitochondrial inner membrane (GO:0005743) 20170117: Eukaryota_PTN000640716 is found in integral component of mitochondrial outer membrane (GO:0031307) 20170117: Eukaryota_PTN000640050 is found in mitochondrial inner membrane (GO:0005743) 20170117: Eukaryota_PTN001941897 is found in integral component of peroxisomal membrane (GO:0005779) 20170117: Eukaryota_PTN001942457 is found in mitochondrial inner membrane (GO:0005743) 20170117: Eukaryota_PTN000640552 is found in mitochondrial inner membrane (GO:0005743) 20170117: Eukaryota_PTN000641656 is found in mitochondrion (GO:0005739) 20170117: Eukaryota_PTN000640628 is found in mitochondrial inner membrane (GO:0005743) 20170117: Eukaryota_PTN001942978 is found in mitochondrion (GO:0005739) 20170117: Eukaryota_PTN000641210 is found in mitochondrion (GO:0005739) 20170117: Eukaryota_PTN002378293 is found in mitochondrion (GO:0005739) 20170117: Eukaryota_PTN000640232 is found in mitochondrion (GO:0005739) 20170117: root_PTN000211803 is found in mitochondrial inner membrane (GO:0005743) 20170117: Eukaryota_PTN001370848 is NOT found in mitochondrial inner membrane (GO:0005743) # biological_process 20170113: Eukaryota_PTN001183376 participates in mitochondrial transport (GO:0006839) 20170116: Eukaryota_PTN001942979 participates in acyl carnitine transport (GO:0006844) 20170116: Eukaryota_PTN001942979 participates in amino acid transport (GO:0006865) 20170113: Eukaryota_PTN000642030 participates in mitochondrial pyrimidine nucleotide import (GO:1990519) 20170116: Eukaryota_PTN001942724 participates in nucleoside transport (GO:0015858) 20170116: Eukaryota_PTN001942541 participates in regulation of mitochondrial membrane potential (GO:0051881) 20170116: Eukaryota_PTN000641105 participates in ADP transport (GO:0015866) 20170116: Eukaryota_PTN000641105 participates in coenzyme A transmembrane transport (GO:0035349) 20170116: Eukaryota_PTN002377805 participates in magnesium ion export from mitochondrion (GO:1990616) 20170116: Embryophyta_PTN001183722 participates in iron ion transport (GO:0006826) 20170116: Eukaryota_PTN001183594 participates in NAD transmembrane transport (GO:0035352) 20170116: node_PTN001182931 participates in response to salt stress (GO:0009651) 20170116: Eukaryota_PTN000641358 participates in mitochondrial ornithine transport (GO:0000066) 20170116: Eukaryota_PTN001183940 participates in dicarboxylic acid transport (GO:0006835) 20170116: Eukaryota_PTN001183940 participates in mitochondrial transport (GO:0006839) 20170116: Eukaryota_PTN000756618 participates in mitochondrial transport (GO:0006839) 20170116: Eukaryota_PTN000756618 participates in phosphate ion transmembrane transport (GO:0035435) 20170116: Eukaryota_PTN000756618 participates in thiosulfate transport (GO:0015709) 20170116: Eukaryota_PTN000756618 participates in malate transmembrane transport (GO:0071423) 20170116: Eukaryota_PTN000756618 participates in oxaloacetate transport (GO:0015729) 20170116: Eukaryota_PTN000756618 participates in succinate transmembrane transport (GO:0071422) 20170116: Eukaryota_PTN000756618 participates in sulfate transport (GO:0008272) 20170116: Eukaryota_PTN000640304 participates in L-glutamate transmembrane transport (GO:0089711) 20170116: Eukaryota_PTN000640306 participates in aspartate transport (GO:0015810) 20170116: Eukaryota_PTN000640306 participates in malate-aspartate shuttle (GO:0043490) 20170113: Eukaryota_PTN001941897 participates in ATP transport (GO:0015867) 20170113: Eukaryota_PTN001941897 participates in ADP transport (GO:0015866) 20170113: Eukaryota_PTN001370848 participates in mitochondrial translation (GO:0032543) 20170116: Eukaryota_PTN002377942 does NOT participate in mitochondrial ornithine transport (GO:0000066) 20170116: Eukaryota_PTN001184222 does NOT participate in mitochondrial ornithine transport (GO:0000066) 20170117: Eukaryota_PTN000640306 participates in aspartate transport (GO:0015810) 20170117: Eukaryota_PTN001183376 participates in carnitine transport (GO:0015879) 20170117: Euteleostomi_PTN000641524 does NOT participate in carnitine transport (GO:0015879) 20170117: Eukaryota_PTN001942541 participates in response to cold (GO:0009409) 20170117: Fungi_PTN001182794 participates in manganese ion transport (GO:0006828) 20170117: Eukaryota_PTN002378075 participates in phosphate ion transmembrane transport (GO:0035435) 20170117: Eukaryota_PTN000756668 participates in thiamine pyrophosphate transport (GO:0030974) 20170117: Eukaryota_PTN000756668 participates in mitochondrial transport (GO:0006839) 20170117: Eukaryota_PTN001942899 participates in succinate transport (GO:0015744) 20170117: Eukaryota_PTN001942899 participates in fumarate transport (GO:0015741) 20170117: Eukaryota_PTN000642156 participates in proton transport (GO:0015992) 20170117: Eukaryota_PTN000642156 participates in mitochondrial transmembrane transport (GO:1990542) 20170117: Opisthokonta_PTN002378102 participates in response to cold (GO:0009409) 20170117: Opisthokonta_PTN002378102 participates in adaptive thermogenesis (GO:1990845) 20170117: Eukaryota_PTN000639904 participates in glycine import (GO:0036233) 20170117: Eukaryota_PTN000641807 participates in mitochondrial iron ion transport (GO:0048250) 20170117: Eukaryota_PTN000641807 participates in iron ion homeostasis (GO:0055072) 20170117: Eukaryota_PTN000640049 participates in mitochondrial transport (GO:0006839) 20170117: Eukaryota_PTN000640049 participates in regulation of mitochondrial membrane permeability (GO:0046902) 20170117: Eukaryota_PTN000640552 participates in mitochondrial citrate transport (GO:0006843) # PRUNED 20170117: root_PTN000211803 participates in mitochondrial transport (GO:0006839) 17 Jan 2017: Viridiplantae_PTN000211863 has been pruned from tree 17 Jan 2017: Bacteria _PTN000211890 has been pruned from tree # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES 16 Jan 2017: Viridiplantae_PTN000211863 has been pruned from tree 16 Jan 2017: Bacteria _PTN000211890 has been pruned from tree 13 Jan 2017: Bacteria _PTN000211890 has been pruned from tree 13 Jan 2017: Viridiplantae_PTN000211863 has been pruned from tree # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).