# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 18 Mar 2016: Updated by: TOUCHUP-v1.14 27 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150603: root_PTN000756324 has function substrate-specific transmembrane transporter activity (GO:0022891) 20150603: Bilateria_PTN001936680 has function organic cation transmembrane transporter activity (GO:0015101) 20150603: Euteleostomi_PTN000628836 has function dopamine transmembrane transporter activity (GO:0005329) 20150603: Euteleostomi_PTN000628836 has function quaternary ammonium group transmembrane transporter activity (GO:0015651) 20150603: Mammalia_PTN000628839 has function norepinephrine transmembrane transporter activity (GO:0005333) 20150603: Mammalia_PTN000628839 has function secondary active organic cation transmembrane transporter activity (GO:0008513) 20150603: Mammalia_PTN000628839 has function acetylcholine transmembrane transporter activity (GO:0005277) 20150603: Theria _PTN000628856 has function choline transmembrane transporter activity (GO:0015220) 20150603: Bilateria_PTN001528763 has function amine transmembrane transporter activity (GO:0005275) 20150603: Bilateria_PTN001528763 has function carnitine transmembrane transporter activity (GO:0015226) 20150603: Theria _PTN000629182 has function nicotinate transporter activity (GO:0090416) 20150603: rosids_PTN001936828 has function carnitine transmembrane transporter activity (GO:0015226) 20150603: Eukaryota_PTN001936837 has function organic anion transmembrane transporter activity (GO:0008514) 20150603: Chordata_PTN000628740 has function cation:cation antiporter activity (GO:0015491) 20150603: Chordata_PTN000628740 has function carnitine transmembrane transporter activity (GO:0015226) 20150603: Bilateria_PTN000628910 has function sodium-independent organic anion transmembrane transporter activity (GO:0015347) 20150603: Bilateria_PTN000628910 has function inorganic anion exchanger activity (GO:0005452) 20150603: Mammalia_PTN000628949 has function urate transmembrane transporter activity (GO:0015143) 20150603: node_PTN001528734 has function glycerophosphodiester transmembrane transporter activity (GO:0001406) 20150603: Dikarya_PTN001175362 has function inorganic phosphate transmembrane transporter activity (GO:0005315) # cellular_component 20150603: root_PTN000756324 is found in integral component of membrane (GO:0016021) 20150603: Eumetazoa_PTN001528943 is found in integral component of plasma membrane (GO:0005887) 20150603: Magnoliophyta_PTN001529024 is found in plant-type vacuole membrane (GO:0009705) 20150603: Magnoliophyta_PTN000629400 is found in plant-type vacuole membrane (GO:0009705) 20150603: Eumetazoa_PTN001175408 is found in integral component of plasma membrane (GO:0005887) 20150603: cellular organisms_PTN000628500 is found in integral component of plasma membrane (GO:0005887) 20150603: Magnoliophyta_PTN000628646 is found in plant-type vacuole membrane (GO:0009705) # biological_process 20150603: Euteleostomi_PTN000628836 participates in dopamine transport (GO:0015872) 20150603: Mammalia_PTN000628839 participates in norepinephrine transport (GO:0015874) 20150603: Mammalia_PTN000628839 participates in neurotransmitter transport (GO:0006836) 20150603: Theria _PTN000628856 participates in choline transport (GO:0015871) 20150603: Bilateria_PTN001528763 participates in organic cation transport (GO:0015695) 20150603: Chordata_PTN000628740 participates in organic cation transport (GO:0015695) 20150603: Chordata_PTN000628740 participates in carnitine transmembrane transport (GO:1902603) 20150603: Chordata_PTN000628740 participates in modified amino acid transport (GO:0072337) 20150603: Chordata_PTN000628740 participates in carnitine metabolic process (GO:0009437) 20150603: Bilateria_PTN000628910 participates in sodium-independent organic anion transport (GO:0043252) 20150603: Mammalia_PTN000628949 participates in urate transport (GO:0015747) 20150603: Boreoeutheria_PTN000629050 participates in renal tubular secretion (GO:0097254) 20150603: node_PTN001528734 participates in glycerophosphodiester transport (GO:0001407) 20150603: Dikarya_PTN001175362 participates in phosphate ion transport (GO:0006817) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).