# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
18 Mar 2016: Updated by: TOUCHUP-v1.14
27 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20140401: node_PTN001173581 has function glutamate receptor activity (GO:0008066) 
20140401: node_PTN000624888 has function group III metabotropic glutamate receptor activity (GO:0001642) 
20140409: Euteleostomi_PTN001173589 has function calcium channel regulator activity (GO:0005246) 
20140409: Euteleostomi_PTN000624917 has function calcium channel regulator activity (GO:0005246) 
20140401: Diptera_PTN000625074 has LOST/MODIFIED function glutamate receptor activity (GO:0008066) 

# cellular_component
20140409: Opisthokonta_PTN001173583 is found in integral component of plasma membrane (GO:0005887) 
20140409: node_PTN000625082 is found in postsynaptic density (GO:0014069) 
20140409: Eumetazoa_PTN001527784 is found in presynaptic membrane (GO:0042734) 

# biological_process
20140410: node_PTN001173581 participates in G-protein coupled glutamate receptor signaling pathway (GO:0007216) 
20140410: node_PTN001173581 participates in regulation of synaptic transmission, glutamatergic (GO:0051966) 
20140410: Bilateria_PTN000625078 participates in protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205) 
20140410: Eumetazoa_PTN001527784 participates in adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway (GO:0007196) 
20140410: Diptera_PTN000625074 does NOT participate in G-protein coupled glutamate receptor signaling pathway (GO:0007216) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
This family contains all metabotropic glutamate receptors. There are three groups of mGluR. Group I contains mGluR1 and 5. Group II contains mGluR2 and 3. Group II contains mGluR4,6,7,8. The tree groups gourp I receptors together, indicating that they are evolved from a common ancestor, but mixes group II and group III receptors. mGlur3 are in the middle of group III members. There is a paper describing the phylogeny of the mGluRs with relatively more correct groupings (PMID 23047810).
Calcium channel regulator activity (GO:0005246) was propagated to Grm7 and Grm2 vertebrate clades, because the MSA on the C terminals are highly conserved in those two subfamilies.. The evidence for Grm3 is not strong. The paper indicated that either Grm2 or Grm3 maybe involved. Later in the evidence for Grm2 and Grm7, there are evidence that both are involved in the inhibition. It is not clear whether Grm3 is involved. Therefore it is not propagated.
The Adenylate cyclase inhibitor activity (GO:0010855) was annotated to the human GRM7. In the reference, it says that the receptor is negatively coupled to adenylate cyclase. we now know that it is through the Go. Therefore, the annotation of the receptor as an inhibitor is not correct.
The annotation of voltage-gated calcium channel activity (GO:0005245) to the mouse GRM7 is not supported by the cited evidence.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).