# HISTORY 27 Mar 2016: Updated by: TOUCHUP-v1.15 18 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150316: root_PTN000618218 has function ATP-dependent RNA helicase activity (GO:0004004) # cellular_component 20150323: Eukaryota_PTN000619358 is found in catalytic step 2 spliceosome (GO:0071013) 20150323: Eukaryota_PTN000619358 is found in U5 snRNP (GO:0005682) 20150323: Eukaryota_PTN000618308 is found in catalytic step 2 spliceosome (GO:0071013) 20150323: Eukaryota_PTN000619776 is found in catalytic step 2 spliceosome (GO:0071013) 20150323: Eukaryota_PTN000619487 is found in mitochondrion (GO:0005739) 20150323: Eukaryota_PTN000620148 is found in spliceosomal complex (GO:0005681) 20150323: Eukaryota_PTN000619958 is found in cytoplasmic mRNA processing body (GO:0000932) 20150323: Eukaryota_PTN000619958 is found in cytoplasmic stress granule (GO:0010494) 20150323: Eumetazoa_PTN001169089 is found in P granule (GO:0043186) 20150323: Eumetazoa_PTN001169089 is found in perinuclear region of cytoplasm (GO:0048471) 20150323: Eukaryota_PTN000619593 is found in cytoplasmic ribonucleoprotein granule (GO:0036464) # biological_process 20150318: root_PTN000618218 participates in RNA secondary structure unwinding (GO:0010501) 20150318: Eukaryota_PTN000619358 participates in RNA splicing, via transesterification reactions (GO:0000375) 20150318: Eumetazoa_PTN001168930 participates in positive regulation of transcription, DNA-templated (GO:0045893) 20150318: Eukaryota_PTN000619776 participates in regulation of gene expression (GO:0010468) 20150318: Eukaryota_PTN000619776 participates in RNA splicing (GO:0008380) 20150318: Eukaryota_PTN000620029 participates in regulation of gene expression (GO:0010468) 20150318: Eukaryota_PTN000620029 participates in translational initiation (GO:0006413) 20150318: Eukaryota_PTN000618950 participates in mRNA splicing, via spliceosome (GO:0000398) 20150318: Eukaryota_PTN000618950 participates in regulation of gene expression (GO:0010468) 20150318: Eukaryota_PTN000620148 participates in regulation of gene expression (GO:0010468) 20150318: Eukaryota_PTN000620148 participates in mRNA splicing, via spliceosome (GO:0000398) 20150318: Eukaryota_PTN000620148 participates in mRNA export from nucleus (GO:0006406) 20150318: Eukaryota_PTN000620148 participates in cellular response to DNA damage stimulus (GO:0006974) 20150318: Eukaryota_PTN000618724 participates in rRNA processing (GO:0006364) 20150318: Eukaryota_PTN000619958 participates in cytoplasmic mRNA processing body assembly (GO:0033962) 20150318: Eukaryota_PTN000619958 participates in regulation of translation (GO:0006417) 20150318: Eukaryota_PTN000618871 participates in rRNA processing (GO:0006364) 20150318: Eukaryota_PTN000619593 participates in chromosome segregation (GO:0007059) 20150318: Eukaryota_PTN000619593 participates in regulation of gene expression (GO:0010468) 20150318: Eukaryota_PTN000619593 participates in translational initiation (GO:0006413) 20150318: Eukaryota_PTN000619859 participates in mRNA export from nucleus (GO:0006406) 20150318: Eukaryota_PTN000619239 participates in rRNA processing (GO:0006364) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES This family contains RNA helicase equivalent to EC 3.6.4.13. There are two subclasses. The first is DEAD-box domain containing ATP-dependent RNA helicase. The second is eukaryotic initiation factor. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).