# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 17 Mar 2016: Updated by: TOUCHUP-v1.14 27 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function # cellular_component 20140815: Ascomycota_PTN000608564 is found in endoplasmic reticulum (GO:0005783) 20140815: Eukaryota_PTN000607277 is found in cytoplasm (GO:0005737) 20140815: Eukaryota_PTN000607277 is found in nucleus (GO:0005634) 20140815: Boreoeutheria_PTN000608931 is found in nucleus (GO:0005634) 20140815: Chordata_PTN001162727 is found in nucleus (GO:0005634) 20140815: Eukaryota_PTN001162931 is found in SAGA complex (GO:0000124) 20140815: Euteleostomi_PTN000608794 is found in nucleus (GO:0005634) 20140815: Opisthokonta_PTN001163306 is found in cytoplasm (GO:0005737) 20140815: Euteleostomi_PTN000608757 is found in nucleus (GO:0005634) 20140815: Euteleostomi_PTN000608144 is found in early endosome (GO:0005769) 20140815: Euteleostomi_PTN000608208 is found in nucleus (GO:0005634) 20140815: Euteleostomi_PTN000608458 is found in cytosol (GO:0005829) 20140815: Euteleostomi_PTN000608458 is found in extrinsic component of endosome membrane (GO:0031313) 20140815: Eumetazoa_PTN001163006 is found in cytoplasm (GO:0005737) # biological_process 20140815: Euteleostomi_PTN000608722 participates in G1/S transition of mitotic cell cycle (GO:0000082) 20140815: Euteleostomi_PTN000608256 participates in ER-associated ubiquitin-dependent protein catabolic process (GO:0030433) 20140815: Euteleostomi_PTN000607883 participates in DNA damage checkpoint (GO:0000077) 20140815: Bilateria_PTN000607280 participates in regulation of apoptotic process (GO:0042981) 20140815: Bilateria_PTN000607280 participates in base-excision repair (GO:0006284) 20140815: Bilateria_PTN000607280 participates in negative regulation of transcription, DNA-templated (GO:0045892) 20140815: Eukaryota_PTN001162931 participates in histone deubiquitination (GO:0016578) 20140815: Eukaryota_PTN001162931 participates in regulation of transcription, DNA-templated (GO:0006355) 20140815: Euteleostomi_PTN000608794 participates in histone H2A K63-linked deubiquitination (GO:0070537) 20140815: Euteleostomi_PTN000608794 participates in positive regulation of transcription, DNA-templated (GO:0045893) 20140815: Euteleostomi_PTN000608757 participates in histone deubiquitination (GO:0016578) 20140815: Euteleostomi_PTN000608144 participates in DNA damage response, signal transduction by p53 class mediator (GO:0030330) 20140815: Euteleostomi_PTN000608144 participates in regulation of autophagy (GO:0010506) 20140815: Eumetazoa_PTN001163006 participates in cell migration (GO:0016477) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: also annotated ubiquitin thiolesterase activity, since it is not wrong, but just redundant to other terms. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).