# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 17 Mar 2016: Updated by: TOUCHUP-v1.14 27 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150819: root_PTN000601268 has function 5-formyltetrahydrofolate cyclo-ligase activity (GO:0030272) 20150819: Opisthokonta_PTN000601270 has function ATPase inhibitor activity (GO:0042030) 20150819: Opisthokonta_PTN000601270 has function ATPase binding (GO:0051117) 20150819: Opisthokonta_PTN000601270 has LOST/MODIFIED function 5-formyltetrahydrofolate cyclo-ligase activity (GO:0030272) # cellular_component 20150819: Eukaryota_PTN000601269 is found in mitochondrion (GO:0005739) # biological_process 20150819: root_PTN000601268 participates in tetrahydrofolate interconversion (GO:0035999) 20150819: root_PTN000601268 participates in folic acid-containing compound biosynthetic process (GO:0009396) 20150819: Opisthokonta_PTN000601270 participates in heme biosynthetic process (GO:0006783) 20150819: Opisthokonta_PTN000601270 participates in negative regulation of ATPase activity (GO:0032780) 20150819: Opisthokonta_PTN000601270 does NOT participate in tetrahydrofolate interconversion (GO:0035999) 20150819: Opisthokonta_PTN000601270 does NOT participate in folic acid-containing compound biosynthetic process (GO:0009396) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).