# HISTORY 13 Oct 2016: Saved by mfeuerma using Paint 2.22 # molecular_function 20161013: root_PTN000601050 has function malic enzyme activity (GO:0004470) 20161013: Eukaryota_PTN000601238 has function malate dehydrogenase (decarboxylating) (NAD+) activity (GO:0004471) 20161013: Dikarya_PTN001157969 has function malate dehydrogenase (decarboxylating) (NAD+) activity (GO:0004471) 20161013: Eukaryota_PTN000601052 has function malate dehydrogenase (decarboxylating) (NADP+) activity (GO:0004473) # cellular_component 20161013: Bacteria _PTN002361249 is found in cytosol (GO:0005829) 20161013: Gammaproteobacteria_PTN000601207 is NOT found in mitochondrion (GO:0005739) 20161013: Eumetazoa_PTN001157886 is found in mitochondrion (GO:0005739) 20161013: Viridiplantae_PTN000601178 is found in chloroplast (GO:0009507) 20161013: Monosiga brevicollis_A9V485 is NOT found in chloroplast (GO:0009507) 20161013: Dikarya_PTN001157914 is NOT found in chloroplast (GO:0009507) 20161013: Viridiplantae_PTN000601169 is found in chloroplast (GO:0009507) 20161013: Eukaryota_PTN000601238 is found in mitochondrion (GO:0005739) 20161013: Dikarya_PTN001157969 is found in mitochondrion (GO:0005739) # biological_process 20161013: root_PTN000601050 participates in malate metabolic process (GO:0006108) 20161013: root_PTN000601050 participates in pyruvate metabolic process (GO:0006090) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).