# HISTORY 27 Mar 2016: Updated by: TOUCHUP-v1.15 17 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140725: Boreoeutheria_PTN000596012 has function transcription factor activity, sequence-specific DNA binding (GO:0003700) # cellular_component 20140725: Boreoeutheria_PTN000596012 is found in nucleus (GO:0005634) 20140725: Eukaryota_PTN000596045 is found in U2-type post-mRNA release spliceosomal complex (GO:0071008) # biological_process 20140725: Boreoeutheria_PTN000596012 participates in negative regulation of transcription, DNA-templated (GO:0045892) 20140725: Eukaryota_PTN000596045 participates in spliceosomal complex disassembly (GO:0000390) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES Did not annotate LIME family - involved in both T cell and B cell signaling, but T cell role is not captured. Need more primary annotations. PG 2'14-07-25 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).