# HISTORY
21 Nov 2016: Saved by mfeuerma using Paint 2.22

# molecular_function
20161121: root_PTN000584058 has function protein kinase activity (GO:0004672) 
20161121: Eukaryota_PTN002356036 has LOST/MODIFIED function protein kinase activity (GO:0004672) 
20161121: Eukaryota_PTN001908451 has function protein serine/threonine kinase activity (GO:0004674) 
20161121: Eukaryota_PTN001147562 has function protein serine/threonine kinase activity (GO:0004674) 
20161121: Eukaryota_PTN001908122 has function protein serine/threonine kinase activity (GO:0004674) 
20161121: Eukaryota_PTN002356460 has function protein serine/threonine kinase activity (GO:0004674) 
20161121: Eukaryota_PTN002356460 has function MAP kinase kinase kinase activity (GO:0004709) 
20161121: Eukaryota_PTN002356460 has function mitogen-activated protein kinase kinase binding (GO:0031434) 
20161121: Eukaryota_PTN002356424 has function protein serine/threonine kinase activity (GO:0004674) 
20161121: Euteleostomi_PTN001147480 has function Rho GTPase binding (GO:0017048) 
20161121: root_PTN000584058 has function signal transducer activity (GO:0004871) 
20161121: Chordata_PTN000723815 has function death receptor binding (GO:0005123) 
20161121: Eukaryota_PTN001510385 has function protein serine/threonine kinase activity (GO:0004674) 
20161121: Eumetazoa_PTN001147668 has function JUN kinase kinase kinase activity (GO:0004706) 
20161121: Chordata_PTN001510283 has function MAP kinase kinase kinase activity (GO:0004709) 
20161121: Euteleostomi_PTN000584124 has function MAP kinase kinase kinase activity (GO:0004709) 

# cellular_component
20161121: Eukaryota_PTN002356036 is found in cytoplasm (GO:0005737) 
20161121: Eukaryota_PTN002356036 is found in plasma membrane (GO:0005886) 
20161121: Eukaryota_PTN001907285 is found in cytoplasm (GO:0005737) 
20161121: Chordata_PTN000723815 is found in ripoptosome (GO:0097342) 
20161121: Eukaryota_PTN001908210 is found in cytoplasm (GO:0005737) 
20161121: Eukaryota_PTN001510385 is found in cytosol (GO:0005829) 
20161121: Eukaryota_PTN001147562 is found in cytoplasm (GO:0005737) 
20161121: Eukaryota_PTN000584061 is found in cytoplasm (GO:0005737) 
20161121: root_PTN000584058 is found in intracellular (GO:0005622) 
20161121: Euteleostomi_PTN000584607 is found in cytosol (GO:0005829) 
20161121: Euteleostomi_PTN000584607 is found in plasma membrane (GO:0005886) 
20161121: Euteleostomi_PTN000584634 is found in plasma membrane (GO:0005886) 
20161121: Deuterostomia_PTN000584576 is found in cytosol (GO:0005829) 
20161121: Deuterostomia_PTN000584576 is found in mitochondrion (GO:0005739) 
20161121: Eumetazoa_PTN001147960 is found in cytoplasm (GO:0005737) 
20161121: Euteleostomi_PTN001147480 is found in cytoplasm (GO:0005737) 
20161121: Euteleostomi_PTN001147480 is found in Golgi apparatus (GO:0005794) 
20161121: Euteleostomi_PTN001147480 is found in endoplasmic reticulum (GO:0005783) 
20161121: Euteleostomi_PTN001147480 is found in mitochondrion (GO:0005739) 
20161121: Euteleostomi_PTN001147480 is found in cytoplasmic vesicle (GO:0031410) 
20161121: Euteleostomi_PTN001147480 is found in mitochondrial membrane (GO:0031966) 
20161121: Euteleostomi_PTN001147480 is found in lysosome (GO:0005764) 
20161121: Euteleostomi_PTN001147480 is found in endosome (GO:0005768) 
20161121: Euteleostomi_PTN001147480 is found in membrane raft (GO:0045121) 
20161121: Euteleostomi_PTN001147480 is found in plasma membrane (GO:0005886) 
20161121: Euteleostomi_PTN001147480 is found in neuron projection (GO:0043005) 
20161121: Euteleostomi_PTN001147480 is found in cytosol (GO:0005829) 
20161121: Euteleostomi_PTN000584124 co-localizes with IkappaB kinase complex (GO:0008385) 
20161121: Chordata_PTN001147636 is found in cytoplasm (GO:0005737) 
20161121: Chordata_PTN001510283 is found in cytoplasm (GO:0005737) 
20161121: Euteleostomi_PTN002356303 is found in centrosome (GO:0005813) 
20161121: Eumetazoa_PTN001510364 is found in focal adhesion (GO:0005925) 
20161121: Eumetazoa_PTN001510364 co-localizes with stress fiber (GO:0001725) 
20161121: Euteleostomi_PTN002356212 is found in nucleus (GO:0005634) 
20161121: Euteleostomi_PTN000584171 is found in nucleus (GO:0005634) 
20161121: Euteleostomi_PTN000584280 is found in neuron projection (GO:0043005) 
20161121: Eukaryota_PTN002356189 is found in Golgi apparatus (GO:0005794) 
20161121: Eukaryota_PTN002356189 is found in nucleus (GO:0005634) 
20161121: Eukaryota_PTN001908211 is found in nucleus (GO:0005634) 
20161121: Euteleostomi_PTN000584548 is found in endoplasmic reticulum (GO:0005783) 
20161121: Euteleostomi_PTN000584548 is found in membrane (GO:0016020) 
20161121: Euteleostomi_PTN000584537 is found in cytosol (GO:0005829) 
20161121: Euteleostomi_PTN000584537 is found in plasma membrane (GO:0005886) 

# biological_process
20161121: root_PTN000584058 participates in protein phosphorylation (GO:0006468) 
20161121: root_PTN000584058 participates in signal transduction (GO:0007165) 
20161121: Eukaryota_PTN002356036 does NOT participate in protein phosphorylation (GO:0006468) 
20161121: Tetrapoda_PTN000584199 participates in necroptotic process (GO:0070266) 
20161121: Eumetazoa_PTN002356039 participates in multicellular organism development (GO:0007275) 
20161121: Tetrapoda_PTN002356042 participates in regulation of adaptive immune response (GO:0002819) 
20161121: Tetrapoda_PTN002356042 participates in T cell homeostasis (GO:0043029) 
20161121: Tetrapoda_PTN002356042 participates in necroptotic process (GO:0070266) 
20161121: root_PTN000584058 participates in intracellular signal transduction (GO:0035556) 
20161121: Eumetazoa_PTN001509881 participates in Ras protein signal transduction (GO:0007265) 
20161121: Euteleostomi_PTN000584537 does NOT participate in Ras protein signal transduction (GO:0007265) 
20161121: Opisthokonta_PTN001510163 participates in positive regulation of MAPK cascade (GO:0043410) 
20161121: Chordata_PTN000723815 participates in necroptotic signaling pathway (GO:0097527) 
20161121: Chordata_PTN000723815 participates in ripoptosome assembly involved in necroptotic process (GO:1901026) 
20161121: Chordata_PTN000723815 participates in apoptotic process (GO:0006915) 
20161121: Chordata_PTN000723815 participates in positive regulation of JNK cascade (GO:0046330) 
20161121: Euteleostomi_PTN000584340 participates in regulation of cardiac conduction (GO:1903779) 
20161121: Euteleostomi_PTN000584340 participates in regulation of heart rate (GO:0002027) 
20161121: Magnoliophyta_PTN002356126 participates in auxin-activated signaling pathway (GO:0009734) 
20161121: Magnoliophyta_PTN002356126 participates in brassinosteroid mediated signaling pathway (GO:0009742) 
20161121: Eukaryota_PTN002356189 participates in actin cytoskeleton organization (GO:0030036) 
20161121: Euteleostomi_PTN000584280 participates in nervous system development (GO:0007399) 
20161121: Eukaryota_PTN002356189 participates in positive regulation of stress fiber assembly (GO:0051496) 
20161121: Eumetazoa_PTN001510364 participates in integrin-mediated signaling pathway (GO:0007229) 
20161121: Eumetazoa_PTN001510364 participates in substrate adhesion-dependent cell spreading (GO:0034446) 
20161121: Eumetazoa_PTN001510364 participates in multicellular organism development (GO:0007275) 
20161121: Eumetazoa_PTN001510364 participates in cell-matrix adhesion (GO:0007160) 
20161121: Euteleostomi_PTN002356303 participates in MAPK cascade (GO:0000165) 
20161121: Euteleostomi_PTN002356303 participates in JNK cascade (GO:0007254) 
20161121: Opisthokonta_PTN001907370 participates in MAPK cascade (GO:0000165) 
20161121: Euteleostomi_PTN000584371 participates in JNK cascade (GO:0007254) 
20161121: Euteleostomi_PTN000584371 participates in positive regulation of JNK cascade (GO:0046330) 
20161121: Euteleostomi_PTN000584371 participates in positive regulation of JUN kinase activity (GO:0043507) 
20161121: Euteleostomi_PTN002356303 participates in positive regulation of apoptotic process (GO:0043065) 
20161121: Euteleostomi_PTN000584371 participates in positive regulation of apoptotic process (GO:0043065) 
20161121: Eumetazoa_PTN001147668 participates in activation of JUN kinase activity (GO:0007257) 
20161121: Chordata_PTN001510283 participates in activation of MAPKK activity (GO:0000186) 
20161121: Chordata_PTN001510283 participates in activation of JUN kinase activity (GO:0007257) 
20161121: Euteleostomi_PTN000584805 participates in innate immune response (GO:0045087) 
20161121: Euteleostomi_PTN000584805 participates in adaptive immune response (GO:0002250) 
20161121: Euteleostomi_PTN000584805 participates in inflammatory response (GO:0006954) 
20161121: Chordata_PTN001147636 participates in MAPK cascade (GO:0000165) 
20161121: Euteleostomi_PTN000584124 participates in JNK cascade (GO:0007254) 
20161121: Euteleostomi_PTN000584124 participates in activation of MAPKK activity (GO:0000186) 
20161121: Euteleostomi_PTN001147480 participates in calcium-mediated signaling (GO:0019722) 
20161121: Euteleostomi_PTN001147480 participates in regulation of dendritic spine morphogenesis (GO:0061001) 
20161121: Euteleostomi_PTN001147480 participates in regulation of autophagy (GO:0010506) 
20161121: Euteleostomi_PTN001147480 participates in negative regulation of autophagosome assembly (GO:1902902) 
20161121: Euteleostomi_PTN001147480 participates in regulation of retrograde transport, endosome to Golgi (GO:1905279) 
20161121: Euteleostomi_PTN001147480 participates in regulation of synaptic vesicle transport (GO:1902803) 
20161121: Euteleostomi_PTN001147480 participates in mitochondrion organization (GO:0007005) 
20161121: Eumetazoa_PTN001147960 participates in positive regulation of MAPK cascade (GO:0043410) 
20161121: Eumetazoa_PTN001147960 participates in regulation of cell cycle (GO:0051726) 
20161121: Eumetazoa_PTN001147960 participates in negative regulation of metaphase/anaphase transition of meiotic cell cycle (GO:1902103) 
20161121: Eukaryota_PTN002356460 participates in positive regulation of ERK1 and ERK2 cascade (GO:0070374) 
20161121: Thalassiosira pseudonana_B8CC40 does NOT participate in negative regulation of apoptotic process (GO:0043066) 
20161121: Eukaryota_PTN002356460 participates in negative regulation of apoptotic process (GO:0043066) 
20161121: Eukaryota_PTN002356460 participates in negative regulation of signal transduction (GO:0009968) 
20161121: Eukaryota_PTN002356460 participates in multicellular organism development (GO:0007275) 
20161121: Euteleostomi_PTN000584124 participates in positive regulation of NF-kappaB transcription factor activity (GO:0051092) 
20161121: Euteleostomi_PTN000584805 participates in positive regulation of NF-kappaB transcription factor activity (GO:0051092) 
20161121: Euteleostomi_PTN002356303 participates in microtubule-based process (GO:0007017) 
20161121: Euteleostomi_PTN000584537 participates in calcium-mediated signaling (GO:0019722) 
20161121: Chordata_PTN000723815 participates in activation of JUN kinase activity (GO:0007257) 
20161121: Eukaryota_PTN002356460 participates in cell differentiation (GO:0030154) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).