# HISTORY 27 Mar 2016: Updated by: TOUCHUP-v1.15 17 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140829: root_PTN000583159 has function Rab guanyl-nucleotide exchange factor activity (GO:0017112) # cellular_component 20140829: root_PTN000583159 is found in TRAPP complex (GO:0030008) # biological_process 20140829: root_PTN000583159 participates in ER to Golgi vesicle-mediated transport (GO:0006888) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: 3 TRAP complexes in yeast, but only one stable TRAP complex in mammals, so no propagation of the 3 complexes. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).