# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 17 Mar 2016: Updated by: TOUCHUP-v1.14 27 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150226: Eukaryota_PTN000582979 has function phospholipid scramblase activity (GO:0017128) # cellular_component 20150226: Eukaryota_PTN000582979 is found in membrane (GO:0016020) 20150226: Tetrapoda_PTN000583005 is found in plasma membrane (GO:0005886) # biological_process 20150226: Murinae_PTN000583059 participates in phosphatidylserine exposure on apoptotic cell surface (GO:0070782) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES Cannot propagate 'phosphatidylserine exposure on apoptotic cell surface' outside of rodents due to the strange phylogeny of this family (multiple duplications after speciations events). # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).