# HISTORY
27 Mar 2016: Updated by: TOUCHUP-v1.15
17 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20160301: Eukaryota_PTN001508259 has function rRNA binding (GO:0019843) 
20160301: Eukaryota_PTN000579859 has function RNA strand annealing activity (GO:0033592) 
20160301: Eukaryota_PTN000579859 has function ribosomal small subunit binding (GO:0043024) 
20160301: Eukaryota_PTN000579859 has function translation initiation factor activity (GO:0003743) 
20160301: Eukaryota_PTN000579859 has function RNA strand-exchange activity (GO:0034057) 

# cellular_component
20160301: Eukaryota_PTN001508259 is found in nucleolus (GO:0005730) 
20160301: Eukaryota_PTN001508259 is found in 90S preribosome (GO:0030686) 
20160301: Eukaryota_PTN000579859 is found in eukaryotic translation initiation factor 4F complex (GO:0016281) 
20160301: Eukaryota_PTN000579859 is found in polysome (GO:0005844) 

# biological_process
20160301: Eukaryota_PTN001508259 participates in ribosomal small subunit biogenesis (GO:0042274) 
20160301: Eukaryota_PTN000579859 participates in formation of translation preinitiation complex (GO:0001731) 
20160301: Eukaryota_PTN000579859 participates in eukaryotic translation initiation factor 4F complex assembly (GO:0097010) 
20160301: Eukaryota_PTN000579859 participates in cytoplasmic translation (GO:0002181) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
This tree is comprised primarily of the translation initiation factors Sc TIF3 and the duplicated vertebrate homologs EIF-4B and EIF-4H.
However, this tree also contains NOP6 from S.cerevisiae, as a separate clade separated from the TIF3 subclade by a duplication node at the root. NOP6 is part of the 90S pre-ribosome in fungi and does does not appear to have homologs in multicellular eukaryotes (SGD web page for NOP6).
The MSA looks reasonable for NOP6 to be related to TIF3, and I have annotated the NOP6 and TIF3 subclades of this tree independently of each other.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).