# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 17 Mar 2016: Updated by: TOUCHUP-v1.14 27 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150820: root_PTN000579295 has function transcription factor activity, sequence-specific DNA binding (GO:0003700) 20150820: root_PTN000579295 has function sequence-specific DNA binding (GO:0043565) 20150820: root_PTN000579295 has function transcription regulatory region DNA binding (GO:0044212) 20150820: Euteleostomi_PTN000579592 has function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001078) 20150820: Euteleostomi_PTN000579358 has function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001078) 20150820: Euteleostomi_PTN000579381 has function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001077) 20150820: Euteleostomi_PTN000352538 has function transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding (GO:0001206) 20150820: Euteleostomi_PTN000579526 has function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001078) 20150820: Euteleostomi_PTN000579507 has function activating transcription factor binding (GO:0033613) 20150820: Euteleostomi_PTN001145386 has function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001078) # cellular_component 20150820: root_PTN000579295 is found in nucleus (GO:0005634) # biological_process 20150820: root_PTN000579295 participates in transcription from RNA polymerase II promoter (GO:0006366) 20150820: root_PTN000579295 participates in multicellular organism development (GO:0007275) 20150820: root_PTN000579295 participates in signal transduction (GO:0007165) 20150820: root_PTN000579295 participates in regulation of transcription, DNA-templated (GO:0006355) 20150820: Bilateria_PTN000579503 participates in neurogenesis (GO:0022008) 20150820: Bilateria_PTN001905569 participates in neurogenesis (GO:0022008) 20150820: Euteleostomi_PTN000579358 participates in negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 20150820: Euteleostomi_PTN000579473 participates in positive regulation of transcription, DNA-templated (GO:0045893) 20150820: Euteleostomi_PTN000579507 participates in positive regulation of transcription, DNA-templated (GO:0045893) 20150820: Euteleostomi_PTN001145386 participates in negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 20150820: Tetrapoda_PTN000579644 participates in negative regulation of transcription from RNA polymerase II promoter (GO:0000122) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).