# HISTORY
27 Mar 2016: Updated by: TOUCHUP-v1.15
17 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20151117: Eukaryota_PTN000574450 has function structural constituent of nuclear pore (GO:0017056) 
20151117: Eukaryota_PTN000574450 has function nucleocytoplasmic transporter activity (GO:0005487) 
20151117: Eukaryota_PTN000574450 has function RNA binding (GO:0003723) 
20151117: Eukaryota_PTN000574450 has function nuclear localization sequence binding (GO:0008139) 

# cellular_component
20151117: Eukaryota_PTN000574450 is found in nuclear pore cytoplasmic filaments (GO:0044614) 

# biological_process
20151117: Eukaryota_PTN000574450 participates in posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery (GO:0000973) 
20151117: Eukaryota_PTN000574450 participates in RNA export from nucleus (GO:0006405) 
20151117: Eukaryota_PTN000574450 participates in protein import into nucleus (GO:0006606) 
20151117: Eukaryota_PTN000574450 participates in telomere tethering at nuclear periphery (GO:0034398) 
# PRUNED

27 Mar 2016: Saccharomycetaceae_PTN001904078 has been pruned from tree

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
17 Mar 2016: Saccharomycetaceae_PTN001904078 has been pruned from tree
This family contains the nuclear pore cytoplasmic filament protein NUP98 (vertebrates), which is represented in S. cerevisiae by Nup116, Nup100, and also the N-terminal portion of Nup145 (aka Nup145N) [Hoelz et al. 2011 (PMID:21495847), Aitchison and Rout 2012 (PMID:22419078), and Kabachinski and Schwartz 2015 (PMID:26046137)].
S. cerevisiae NUP49 and the Ashbya sequence ASHGO_ADL045W were pruned because the reviews I have referred to consider NUP49 to be equivalent to vertebrate NUP58, which comprises the PTHR13437 family (NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1).  NUP49 is clearly missing some blocks of highly conserved residues compared to the other Sc sequences in this family. However, from the MSA, it looks like NUP49 is somewhat related to the NUP100, NUP116, and NUP145N sequences that do belong in this family; I might not have picked up on it not belonging in this family from the MSA alone.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).