# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 17 Mar 2016: Updated by: TOUCHUP-v1.14 26 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150805: Eukaryota_PTN000573351 has function nucleic acid binding (GO:0003676) 20150805: Bilateria_PTN000573360 has function transcription regulatory region sequence-specific DNA binding (GO:0000976) # cellular_component 20150805: Eukaryota_PTN000573351 is found in nucleus (GO:0005634) # biological_process 20150805: Eukaryota_PTN000573351 participates in mRNA splicing, via spliceosome (GO:0000398) 20150805: Bilateria_PTN000573360 participates in regulation of transcription, DNA-templated (GO:0006355) 20150805: Euteleostomi_PTN000573447 participates in alternative mRNA splicing, via spliceosome (GO:0000380) 20150805: Tetrapoda_PTN000573547 participates in regulation of alternative mRNA splicing, via spliceosome (GO:0000381) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).