# HISTORY
26 Mar 2016: Updated by: TOUCHUP-v1.15
17 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20141124: Eukaryota_PTN001501163 has function guanylate kinase activity (GO:0004385) 
20141124: Eukaryota_PTN001501163 has function ionotropic glutamate receptor binding (GO:0035255) 

# cellular_component
20141124: Eukaryota_PTN001501163 is found in basolateral plasma membrane (GO:0016323) 
20141124: Eukaryota_PTN001501163 is found in postsynaptic membrane (GO:0045211) 
20141124: Eukaryota_PTN001501163 co-localizes with ionotropic glutamate receptor complex (GO:0008328) 
20141124: Eukaryota_PTN001501163 is found in postsynaptic density (GO:0014069) 
20141124: Euteleostomi_PTN000563621 is NOT found in basolateral plasma membrane (GO:0016323) 

# biological_process
20141124: Eukaryota_PTN001501163 participates in synaptic transmission (GO:0007268) 
20141124: Eukaryota_PTN001501163 participates in nervous system development (GO:0007399) 
20141124: Eukaryota_PTN001501163 participates in receptor localization to synapse (GO:0097120) 
20141124: Eukaryota_PTN001501163 participates in establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197) 
20141124: Eukaryota_PTN001501163 participates in receptor clustering (GO:0043113) 
20141124: Euteleostomi_PTN000563621 does NOT participate in establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED
## Annotations that have been removed.
20141124: Eukaryota_PTN001501163 to embryo development (GO:0009790) is an excluded term and not to be used for annotation

# NOTES
This is a Dlg family. The top part of the tree is a small clade of drsophila Grip homologues that also contain PDZ domain. They should be moved to the GRIP family PTHR10316, which is also a PDZ domain contain family.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).