# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 17 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140212: Boreoeutheria_PTN000558864 has function ligand-dependent nuclear receptor transcription coactivator activity (GO:0030374) # cellular_component 20140212: Boreoeutheria_PTN000558864 is found in nuclear speck (GO:0016607) # biological_process 20140212: Boreoeutheria_PTN000558864 participates in BMP signaling pathway (GO:0030509) 20140212: Euarchontoglires_PTN000558809 participates in regulation of apoptotic process (GO:0042981) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES This family has several quite divergent subfamilies, so it's not possible to assign any annotations to the root. Proteins in the ZCCHC12 clade have a zinc finger; others do not have domains. Evidence for CCDC8's role as a negative regulator of phosphatase activity not sufficient for propagation. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).