# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 17 Mar 2016: Updated by: TOUCHUP-v1.14 17 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20151022: Eukaryota_PTN000555199 has function CTD phosphatase activity (GO:0008420) # cellular_component 20151022: Eukaryota_PTN000555199 is found in DNA-directed RNA polymerase II, holoenzyme (GO:0016591) # biological_process 20151022: Eukaryota_PTN000555199 participates in dephosphorylation of RNA polymerase II C-terminal domain (GO:0070940) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES This family comprises the FCP1 RNA polymerase II CTD phosphatases. In plants, there have been duplications such that there are multiple CTD phosphatases of this class that have both unique and overlapping roles in regulation of transcription (Bang et al. 2006 PMID:16905668; Koiwa et al. 2002 PMID:12149434). # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).