# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
17 Mar 2016: Updated by: TOUCHUP-v1.14
17 Mar 2016: Updated by: TOUCHUP-v1.14
26 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20140730: node_PTN000553509 has function microtubule-severing ATPase activity (GO:0008568) 
20140730: Eukaryota_PTN001129792 has LOST/MODIFIED function microtubule-severing ATPase activity (GO:0008568) 
20140730: Eukaryota_PTN000553912 has LOST/MODIFIED function microtubule-severing ATPase activity (GO:0008568) 

# cellular_component
20140623: node_PTN000553509 is found in nucleus (GO:0005634) 

# biological_process
20140730: node_PTN000553509 participates in cytoplasmic microtubule organization (GO:0031122) 
20140730: Eukaryota_PTN000553912 participates in vacuole organization (GO:0007033) 
20140730: Eukaryota_PTN000553645 participates in regulation of double-strand break repair via homologous recombination (GO:0010569) 
20140730: Eukaryota_PTN001129792 does NOT participate in cytoplasmic microtubule organization (GO:0031122) 
20140730: Eukaryota_PTN000553912 does NOT participate in cytoplasmic microtubule organization (GO:0031122) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
BP: FIGNL1's RAD51 binding domain (FRBD) is required for "regulation of double-strand break repair via homologous recombination" (GO:0000724) activity. Decision was made to propagate the term only to Eukaryota_PTN000553645 as the Most Recent Common Ancestor for this biological process for the FIGNL1 gene.  FIGNL1 and its homologs contain also an AAA superfamily domain, as well as a vsp4 domain. The required FRBD domain is only present in this family. Members from other clades were reviewed, for example KATNAL2 and VPS4. Neither family had the required FRBD and the former did not have a vsp4 domain either.
BP: cytoplasmic microtubule organization
MF: microtubule-severing ATPase activity (GO:0008568) confirmed in four of the seven Eukaryotic clusters (clades), which contain either Spastin, Fidgetin, Fidgentin-like or Katanin genes. Term is child of Hydrolase activity and ATPase activity ("Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP"). Did not propagate to the root of the tree because of controversy about their prescece in Archaea. Added a "NOT" annotation to the clade containing the VSP4/SKD1 genes because of lack of evidence confirming this MF in the clade.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).