# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 17 Mar 2016: Updated by: TOUCHUP-v1.14 17 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150320: node_PTN000553036 has function proteasome-activating ATPase activity (GO:0036402) 20150320: node_PTN000553036 has function TBP-class protein binding (GO:0017025) # cellular_component 20150320: node_PTN000553036 is found in cytosolic proteasome complex (GO:0031597) 20150320: node_PTN000553036 is found in proteasome regulatory particle, base subcomplex (GO:0008540) 20150320: node_PTN000553036 is found in nuclear proteasome complex (GO:0031595) 20150320: Euryarchaeota_PTN001129598 is NOT found in nuclear proteasome complex (GO:0031595) 20150320: Archaea_PTN000553475 is NOT found in nuclear proteasome complex (GO:0031595) # biological_process 20150320: node_PTN000553036 participates in ER-associated ubiquitin-dependent protein catabolic process (GO:0030433) 20150320: node_PTN000553036 participates in positive regulation of RNA polymerase II transcriptional preinitiation complex assembly (GO:0045899) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: The 19S regulatory subunit of the proteasome has also a proteasome-independent function in transcription initiation. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).