# HISTORY
26 Mar 2016: Updated by: TOUCHUP-v1.15
17 Mar 2016: Updated by: TOUCHUP-v1.14
17 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20150916: root_PTN001128910 has function RNA binding (GO:0003723) 
20150916: node_PTN000552321 has function p53 binding (GO:0002039) 
20150916: Euteleostomi_PTN000552431 has function mRNA 3'-UTR binding (GO:0003730) 
20150916: Euteleostomi_PTN000753854 has function double-stranded RNA binding (GO:0003725) 

# cellular_component
20150916: Euteleostomi_PTN000552431 is found in neuronal cell body (GO:0043025) 
20150916: Euteleostomi_PTN000552322 is found in nucleus (GO:0005634) 
20150916: Eukaryota_PTN001128911 is found in U4/U6 x U5 tri-snRNP complex (GO:0046540) 

# biological_process
20150916: node_PTN000552321 participates in intrinsic apoptotic signaling pathway by p53 class mediator (GO:0072332) 
20150916: Euteleostomi_PTN000552431 participates in mRNA localization resulting in posttranscriptional regulation of gene expression (GO:0010609) 
20150916: Euteleostomi_PTN000552431 participates in regulation of cytoplasmic translation (GO:2000765) 
20150916: Eukaryota_PTN001128911 participates in mRNA splicing, via spliceosome (GO:0000398) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
This is a complex tree with a duplication node at the root. When viewing the condensed MSA (Entire alignment unchecked), there is a clear conserved core, however when viewing the full alignment, it is clear that there has been a lot of divergence also.
The first subclade Eukaryota_PTN000552286 contains some duplication nodes below which are many proteins described as RNA binding zinc-finger proteins that interact with p53 and regulate apoptotic processes, so I have propagated this to as high as I feel justified by the presence of experimental descriptions of a role in p53-dependent processes.
The second subclade (Eukaryota_PTN001891020) is primarily found in Magnoliophyta and does not contain experimental data at this time.
The third subclade (Eukaryota_PTN001128911) contains the SNU23 protein found in the U4/U6.U5 tri-snRNP involved in spliceosomal RNA splicing.
PTN001128910 - root duplication node
- Eukaryota_PTN000552286
-- Eumetazoa_PTN001128942
- PTN000552321
-- Craniata-Cephalochordata_PTN001128945
--- PTN001890912 - duplication node
---- Osteichthyes_PTN000552528 - ZMAT4
---- Osteichthyes_PTN000552351 - ZMAT1
---- Osteichthyes_PTN000552531 - ZNF385D
---- Osteichthyes_PTN000552431 - ZNF385A
---- Osteichthyes_PTN000552322 - ZNF385B
---- Osteichthyes_PTN000552492 - ZNF385C
---- Osteichthyes_PTN000753854 - ZFP346
--- BRAFL_GRAFLDRAFT_228070
-- PTN001890945 - duplication node
--- Osteichthyes_PTN000552406 - ZMAT3
--- CHICK_LOC420992
- Eukaryota_PTN001891020 - Magnoliophyta_PTN000552560 + THAPS_THAPSDRAFT_264318
- Eukaryota_PTN001128911 - SNU23

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).