# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 17 Mar 2016: Updated by: TOUCHUP-v1.14 17 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component # biological_process 20140729: Opisthokonta_PTN000548993 participates in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000467) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES The family contains ERI ribonucleases, but the top of the tree contains a few DNA polymerase III genes. Based on the MSA, they seem to be related so those sequences are not pruned. MF: Only ERI1 is annotated to 3-5 exonuclease, but based on the following paper (Pubmed=17135487), the term is propagated to the ancestor of all three ERI clades. BP: RNA phosphodiester bond hydrolysis seems to be redundant to exoribonuclease. So did not propagate. However, the term is inherited # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).