# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
17 Mar 2016: Updated by: TOUCHUP-v1.14
17 Mar 2016: Updated by: TOUCHUP-v1.14
26 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20150805: Eukaryota_PTN000548413 has function ubiquitin protein ligase activity (GO:0061630) 
20150805: Eukaryota_PTN001495439 has function SUMO polymer binding (GO:0032184) 
20150805: Metazoa_PTN001888893 has function transcription factor binding (GO:0008134) 

# cellular_component
20150805: Eukaryota_PTN000548413 is found in nucleus (GO:0005634) 
20150805: Eukaryota_PTN001495439 is found in SUMO-targeted ubiquitin ligase complex (GO:0033768) 
20150805: Euteleostomi_PTN000548418 co-localizes with PML body (GO:0016605) 

# biological_process
20150805: Eukaryota_PTN000548413 participates in proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161) 
20150805: Eukaryota_PTN000548413 participates in protein ubiquitination (GO:0016567) 
20150805: Eukaryota_PTN001495439 participates in negative regulation of protein sumoylation (GO:0033234) 
20150805: Metazoa_PTN001888893 participates in positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 
20150805: Embryophyta_PTN001126931 participates in reciprocal meiotic recombination (GO:0007131) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).