# HISTORY
26 Mar 2016: Updated by: TOUCHUP-v1.15
17 Mar 2016: Updated by: TOUCHUP-v1.14
17 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20150813: Opisthokonta_PTN000543299 has function phosphatidylinositol binding (GO:0035091) 

# cellular_component
20150813: Eukaryota_PTN000543297 is found in plasma membrane (GO:0005886) 
20150813: Eukaryota_PTN000543297 is found in cytoplasm (GO:0005737) 
20150813: Opisthokonta_PTN000543299 is found in early endosome (GO:0005769) 
20150813: Opisthokonta_PTN000543299 is found in late endosome (GO:0005770) 
20150813: Opisthokonta_PTN000543299 is found in extrinsic component of endosome membrane (GO:0031313) 

# biological_process
20150813: Eukaryota_PTN000543297 participates in negative regulation of ion transport (GO:0043271) 
20150813: Eukaryota_PTN000543297 participates in negative regulation of ATPase activity (GO:0032780) 
20150813: Eukaryota_PTN000543297 participates in regulation of membrane potential (GO:0042391) 
20150813: Opisthokonta_PTN000543299 participates in endosome to lysosome transport (GO:0008333) 
20150813: Opisthokonta_PTN000543299 participates in protein targeting to lysosome (GO:0006622) 
20150813: Opisthokonta_PTN000543299 participates in early endosome to late endosome transport (GO:0045022) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
MAF: Duplication at the root leads to 2 very different functions. However, sequence alignments show node PTN000543297 and sub-node PTN001885673 closer, and sub-node PTHR000543299 more divergent. So I've only propagated the endosomal transport functions within PTHR000543299.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).