# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 17 Mar 2016: Updated by: TOUCHUP-v1.14 17 Mar 2016: Updated by: TOUCHUP-v1.14 26 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20140903: Eukaryota_PTN001122685 has function protein serine/threonine kinase activity (GO:0004674) # cellular_component 20140903: Eukaryota_PTN001122685 is found in cytoplasm (GO:0005737) # biological_process 20140903: Eukaryota_PTN001122685 participates in protein autophosphorylation (GO:0046777) 20140903: Deuterostomia_PTN001122687 participates in negative regulation of apoptotic process (GO:0043066) 20140903: Deuterostomia_PTN001122687 participates in regulation of mitotic cell cycle (GO:0007346) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: Expected to be a big family, but when collapsing fish, not much left. Proto-oncogenes. Phosphorylate and regulate MYC, so most BPs are just indirect phenotypes. Negative regulation of apoptosis shown in many studies, een if it might be indirect. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).