# HISTORY 26 Oct 2016: Saved by mfeuerma using Paint 2.22 # molecular_function 20161026: Eukaryota_PTN002344267 has function protein serine/threonine kinase activity (GO:0004674) 20161026: Bilateria_PTN000540281 contributes to function IkappaB kinase activity (GO:0008384) # cellular_component 20161026: Bilateria_PTN000540281 is found in IkappaB kinase complex (GO:0008385) 20161026: Eukaryota_PTN002344267 is found in cytoplasm (GO:0005737) # biological_process 20161026: Eukaryota_PTN002344267 participates in peptidyl-serine phosphorylation (GO:0018105) 20161026: Bilateria_PTN000540281 participates in innate immune response (GO:0045087) 20161026: Bilateria_PTN000540281 participates in positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 20161026: node_PTN000540280 participates in innate immune response (GO:0045087) 20161026: Branchiostoma floridae_C3ZXG1 does NOT participate in inflammatory response (GO:0006954) 20161026: Branchiostoma floridae_C3YFT5 does NOT participate in inflammatory response (GO:0006954) 20161026: Strongylocentrotus purpuratus_W4XXU0 does NOT participate in inflammatory response (GO:0006954) 20161026: Pancrustacea_PTN001121877 does NOT participate in inflammatory response (GO:0006954) 20161026: Bilateria_PTN000540281 participates in inflammatory response (GO:0006954) 20161026: Bilateria_PTN000540281 participates in anatomical structure morphogenesis (GO:0009653) 20161026: Bilateria_PTN000540281 participates in tumor necrosis factor-mediated signaling pathway (GO:0033209) 20161026: Bilateria_PTN000540281 participates in positive regulation of NF-kappaB transcription factor activity (GO:0051092) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).