# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 26 Mar 2016: Updated by: TOUCHUP-v1.15 17 Mar 2016: Updated by: TOUCHUP-v1.14 17 Mar 2016: Updated by: TOUCHUP-v1.14 06 May 2016: Updated by: TOUCHUP-v1.18 # molecular_function 20160301: root_PTN000537561 has function Rab GTPase binding (GO:0017137) 20160301: root_PTN000537561 has function GTPase activator activity (GO:0005096) 20160301: Eukaryota_PTN000537877 has function ADP-ribosylarginine hydrolase activity (GO:0003875) 20160301: Eukaryota_PTN000537877 has LOST/MODIFIED function Rab GTPase binding (GO:0017137) 20160301: Eukaryota_PTN000537877 has LOST/MODIFIED function GTPase activator activity (GO:0005096) # cellular_component 20160301: root_PTN000537561 is found in intracellular (GO:0005622) 20160301: root_PTN000537561 is found in endomembrane system (GO:0012505) 20160301: Euarchontoglires_PTN001490827 is found in cytoplasmic vesicle (GO:0031410) 20160301: Ascomycota_PTN000538320 is found in mitotic spindle pole body (GO:0044732) 20160301: Eukaryota_PTN000537876 is found in endosome membrane (GO:0010008) 20160301: Eukaryota_PTN000537876 is found in autophagosome (GO:0005776) 20160301: Metazoa_PTN001883611 is found in early endosome (GO:0005769) 20160301: Bilateria_PTN000538498 is found in autophagosome (GO:0005776) 20160301: Bilateria_PTN000538677 is found in recycling endosome (GO:0055037) 20160301: Bilateria_PTN000538677 is found in autophagosome (GO:0005776) 20160301: Metazoa_PTN001883803 is found in primary cilium (GO:0072372) 20160301: Fungi_PTN001120197 is found in Golgi apparatus (GO:0005794) 20160301: Eukaryota_PTN000537877 is NOT found in endomembrane system (GO:0012505) # biological_process 20160301: root_PTN000537561 participates in regulation of vesicle fusion (GO:0031338) 20160301: root_PTN000537561 participates in intracellular protein transport (GO:0006886) 20160301: root_PTN000537561 participates in activation of GTPase activity (GO:0090630) 20160301: Eukaryota_PTN000537877 participates in cellular protein modification process (GO:0006464) 20160301: Ascomycota_PTN000538320 participates in negative regulation of septation initiation signaling (GO:0031030) 20160301: Eukaryota_PTN000537876 participates in autophagy (GO:0006914) 20160301: Eukaryota_PTN000537876 participates in response to starvation (GO:0042594) 20160301: Metazoa_PTN001883611 participates in receptor recycling (GO:0001881) 20160301: Metazoa_PTN001883616 participates in regulation of autophagosome maturation (GO:1901096) 20160301: Bilateria_PTN000538677 participates in regulation of autophagosome assembly (GO:2000785) 20160301: Metazoa_PTN001883803 participates in regulation of cilium assembly (GO:1902017) 20160301: Tetrapoda_PTN000753349 participates in regulation of cilium assembly (GO:1902017) 20160301: Eukaryota_PTN000537877 does NOT participate in regulation of vesicle fusion (GO:0031338) 20160301: Eukaryota_PTN000537877 does NOT participate in intracellular protein transport (GO:0006886) 20160301: Eukaryota_PTN000537877 does NOT participate in activation of GTPase activity (GO:0090630) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).