# HISTORY
26 Mar 2016: Updated by: TOUCHUP-v1.15
17 Mar 2016: Updated by: TOUCHUP-v1.14
17 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20140901: root_PTN000532910 has function serine-type endopeptidase activity (GO:0004252) 
20140901: Alveolata_PTN000532985 has LOST/MODIFIED function serine-type endopeptidase activity (GO:0004252) 
20140901: Chlamydomonas reinhardtii_A8JBF0 has LOST/MODIFIED function serine-type endopeptidase activity (GO:0004252) 
20140901: Opisthokonta_PTN001117529 has LOST/MODIFIED function serine-type endopeptidase activity (GO:0004252) 

# cellular_component
20140902: Eukaryota_PTN001117658 is found in mitochondrial inner membrane (GO:0005743) 
20140901: Opisthokonta_PTN001117493 is found in integral component of membrane (GO:0016021) 
20140901: Opisthokonta_PTN001117529 is found in endoplasmic reticulum membrane (GO:0005789) 

# biological_process
20140901: root_PTN000532910 participates in protein processing (GO:0016485) 
20140901: Opisthokonta_PTN001117529 participates in regulation of protein secretion (GO:0050708) 
20140901: Opisthokonta_PTN001117529 participates in regulation of epidermal growth factor receptor signaling pathway (GO:0042058) 
20140901: Opisthokonta_PTN001117529 does NOT participate in protein processing (GO:0016485) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
Active site of yeast ptotein contains GASG. According to PMID: 21439629, the Drosophila protein containing GPSG is active, while the human containing GPAG isn't, so I added 'NOT/IKR' to all sequences with a Proline at this position.
I have found no data related to the activity of human RHBDL1 and RHBDL3, having Glycine and Serine, respectively, rather than Alanine (GGSG and GSSG).

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).