# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 17 Mar 2016: Updated by: TOUCHUP-v1.14 17 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150701: Eukaryota_PTN000302083 contributes to function histone methyltransferase activity (H3-K4 specific) (GO:0042800) 20150701: Eukaryota_PTN001109634 has function transcription cofactor activity (GO:0003712) 20150701: Opisthokonta_PTN000521836 has function histone binding (GO:0042393) 20150701: Opisthokonta_PTN000521836 has function transcriptional repressor activity, RNA polymerase II transcription factor binding (GO:0001191) 20150701: Eukaryota_PTN000457694 contributes to function second spliceosomal transesterification activity (GO:0000386) 20150701: Eukaryota_PTN000752735 has function microtubule binding (GO:0008017) 20150701: Eukaryota_PTN000752735 has function dynein binding (GO:0045502) 20150701: Eukaryota_PTN001483273 contributes to function telomerase activity (GO:0003720) 20150701: Eukaryota_PTN000521776 has function ubiquitin protein ligase activity (GO:0061630) # cellular_component 20150701: Eukaryota_PTN000302083 is found in Set1C/COMPASS complex (GO:0048188) 20150701: Opisthokonta_PTN001108918 is found in U5 snRNP (GO:0005682) 20150701: Opisthokonta_PTN001108918 is found in precatalytic spliceosome (GO:0071011) 20150701: Opisthokonta_PTN001108918 is found in catalytic step 2 spliceosome (GO:0071013) 20150701: Euteleostomi_PTN001871423 is found in nucleus (GO:0005634) 20150701: Euteleostomi_PTN001871423 is found in spindle pole (GO:0000922) 20150701: Eukaryota_PTN001871445 is found in intracellular (GO:0005622) 20150701: Opisthokonta_PTN001871492 is found in cytoplasm (GO:0005737) 20150701: Eukaryota_PTN001109634 is found in SAGA complex (GO:0000124) 20150701: Opisthokonta_PTN000521836 is found in transcription elongation factor complex (GO:0008023) 20150701: Opisthokonta_PTN000521836 is found in transcriptional repressor complex (GO:0017053) 20150701: Opisthokonta_PTN000521836 is found in Elongator holoenzyme complex (GO:0033588) 20150701: Opisthokonta_PTN000521836 is found in histone acetyltransferase complex (GO:0000123) 20150701: Fungi_PTN001011040 is found in integral component of endoplasmic reticulum membrane (GO:0030176) 20150701: Eukaryota_PTN000457694 is found in catalytic step 2 spliceosome (GO:0071013) 20150701: Opisthokonta_PTN001483500 is found in intracellular (GO:0005622) 20150701: Dikarya_PTN001871748 is found in SAGA complex (GO:0000124) 20150701: Euteleostomi_PTN000521600 is found in ciliary basal body (GO:0036064) 20150701: Euteleostomi_PTN000521600 is found in primary cilium (GO:0072372) 20150701: Eukaryota_PTN000752735 is found in microtubule (GO:0005874) 20150701: Eukaryota_PTN000752735 is found in cell cortex (GO:0005938) 20150701: Eukaryota_PTN000752735 is found in centrosome (GO:0005813) 20150701: Eukaryota_PTN000752735 is found in kinetochore (GO:0000776) 20150701: Eukaryota_PTN000752735 is found in microtubule associated complex (GO:0005875) 20150701: Eukaryota_PTN001871829 is found in spindle pole (GO:0000922) 20150701: Eukaryota_PTN001871829 is found in pericentriolar material (GO:0000242) 20150701: Eukaryota_PTN001871829 is found in centriole (GO:0005814) 20150701: Eukaryota_PTN001871829 is found in ciliary basal body (GO:0036064) 20150701: Eukaryota_PTN001483273 is found in telomerase holoenzyme complex (GO:0005697) 20150701: Eukaryota_PTN001483273 is found in nuclear matrix (GO:0016363) 20150701: Eukaryota_PTN000521776 is found in nucleoplasm (GO:0005654) 20150701: Fungi_PTN001109438 is NOT found in centrosome (GO:0005813) # biological_process 20150701: Opisthokonta_PTN001108918 participates in RNA splicing (GO:0008380) 20150701: Opisthokonta_PTN001871417 participates in positive regulation of mitotic nuclear division (GO:0045840) 20150701: Euteleostomi_PTN001871423 participates in neurogenesis (GO:0022008) 20150701: Euteleostomi_PTN001871423 participates in mitotic spindle organization (GO:0007052) 20150701: Eukaryota_PTN001109634 participates in histone acetylation (GO:0016573) 20150701: Eukaryota_PTN001109634 participates in regulation of transcription from RNA polymerase II promoter (GO:0006357) 20150701: Fungi_PTN001011040 participates in regulation of COPII vesicle coating (GO:0003400) 20150701: Eukaryota_PTN000457694 participates in generation of catalytic spliceosome for second transesterification step (GO:0000350) 20150701: Euteleostomi_PTN000521600 participates in cilium morphogenesis (GO:0060271) 20150701: Opisthokonta_PTN000752736 participates in nuclear migration (GO:0007097) 20150701: Opisthokonta_PTN000752736 participates in reproduction (GO:0000003) 20150701: Opisthokonta_PTN000752736 participates in vesicle transport along microtubule (GO:0047496) 20150701: Opisthokonta_PTN000752736 participates in establishment of mitotic spindle orientation (GO:0000132) 20150701: Opisthokonta_PTN000752736 participates in regulation of microtubule motor activity (GO:2000574) 20150701: Opisthokonta_PTN000752736 participates in microtubule organizing center organization (GO:0031023) 20150701: Bilateria_PTN000522053 participates in retrograde axonal transport (GO:0008090) 20150701: Bilateria_PTN000522053 participates in germ cell development (GO:0007281) 20150701: Bilateria_PTN000522053 participates in neurogenesis (GO:0022008) 20150701: Eukaryota_PTN001871829 participates in protein localization to centrosome (GO:0071539) 20150701: Eukaryota_PTN001483273 participates in telomere maintenance via recombination (GO:0000722) 20150701: Eukaryota_PTN001483939 participates in cellular response to starvation (GO:0009267) 20150701: Eukaryota_PTN000521776 participates in positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: Big family, but not much known and very different functions, locations and porcesses. Nothing to annotate at the root. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).