# HISTORY 11 nov. 2016: Saved by normandecoulombe using Paint 2.22 # molecular_function 20161111: Chordata_PTN001107229 has function Rac guanyl-nucleotide exchange factor activity (GO:0030676) # cellular_component 20161111: Chordata_PTN001107229 is found in plasma membrane (GO:0005886) 20161111: Eukaryota_PTN001482048 is found in cytoplasm (GO:0005737) # biological_process 20161111: Chordata_PTN001107229 participates in G-protein coupled receptor signaling pathway (GO:0007186) 20161111: Eumetazoa_PTN001107228 participates in negative regulation of TOR signaling (GO:0032007) 20161111: Eumetazoa_PTN001107228 participates in negative regulation of protein kinase activity (GO:0006469) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).