# HISTORY 16 Jun 2016: Saved by mfeuerma using Paint 2.0-beta19 # molecular_function 20160616: Eukaryota_PTN001103191 has function ubiquitin-protein transferase activity (GO:0004842) 20160616: Eukaryota_PTN001103191 has function ubiquitin binding (GO:0043130) # cellular_component 20160616: Eumetazoa_PTN001103197 is found in LUBAC complex (GO:0071797) 20160616: Eukaryota_PTN001103191 is found in ubiquitin ligase complex (GO:0000151) # biological_process 20160616: Eukaryota_PTN001103191 participates in protein linear polyubiquitination (GO:0097039) 20160616: Eukaryota_PTN001103191 participates in proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161) 20160616: node_PTN000752489 participates in positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).