# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
17 Mar 2016: Updated by: TOUCHUP-v1.14
26 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20150930: root_PTN000280277 has function ubiquitin protein ligase activity (GO:0061630) 
20150930: Eukaryota_PTN001864137 has function ubiquitin-specific protease binding (GO:1990381) 
20150930: Eukaryota_PTN001864137 has function ubiquitin protein ligase activity involved in ERAD pathway (GO:1904264) 
20150930: Eukaryota_PTN000967687 has function ubiquitin protein ligase activity involved in ERAD pathway (GO:1904264) 
20150930: Eukaryota_PTN000967687 has function unfolded protein binding (GO:0051082) 
20150930: Eukaryota_PTN000967687 has function ubiquitin-specific protease binding (GO:1990381) 

# cellular_component
20150930: Eukaryota_PTN001863888 is found in nucleus (GO:0005634) 
20150930: Eukaryota_PTN001863888 is found in cytoplasm (GO:0005737) 
20150930: Opisthokonta_PTN001863933 is found in nucleus (GO:0005634) 
20150930: Bilateria_PTN000967628 is found in endoplasmic reticulum (GO:0005783) 
20150930: Eukaryota_PTN001864113 is found in nucleus (GO:0005634) 
20150930: Eukaryota_PTN001864113 is found in cytoplasm (GO:0005737) 
20150930: Eukaryota_PTN001864137 is found in Hrd1p ubiquitin ligase ERAD-M complex (GO:0000838) 
20150930: Eukaryota_PTN000967750 is found in endoplasmic reticulum membrane (GO:0005789) 
20150930: Magnoliophyta_PTN000510213 is found in nucleus (GO:0005634) 
20150930: Magnoliophyta_PTN000510213 is found in cytosol (GO:0005829) 
20150930: Eukaryota_PTN000341955 is found in cytoplasm (GO:0005737) 
20150930: Eukaryota_PTN000341955 is found in nucleus (GO:0005634) 
20150930: Eukaryota_PTN001864293 is found in cytoplasm (GO:0005737) 
20150930: Eukaryota_PTN000967687 is found in endoplasmic reticulum quality control compartment (GO:0044322) 
20150930: Eukaryota_PTN000967687 is found in Derlin-1 retrotranslocation complex (GO:0036513) 
20150930: Eukaryota_PTN000967687 is found in Hrd1p ubiquitin ligase complex (GO:0000836) 
20150930: Eukaryota_PTN001864364 is found in plasma membrane (GO:0005886) 
20150930: Eukaryota_PTN001864384 is found in plasma membrane (GO:0005886) 
20150930: Eukaryota_PTN001102293 is found in cytosol (GO:0005829) 

# biological_process
20150930: root_PTN000280277 participates in protein polyubiquitination (GO:0000209) 
20150930: root_PTN000280277 participates in protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787) 
20150930: root_PTN000280277 participates in proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161) 
20150930: Eukaryota_PTN001864137 participates in endoplasmic reticulum unfolded protein response (GO:0030968) 
20150930: Eukaryota_PTN001864137 participates in ER-associated ubiquitin-dependent protein catabolic process (GO:0030433) 
20150930: Magnoliophyta_PTN000510213 participates in negative regulation of abscisic acid-activated signaling pathway (GO:0009788) 
20150930: Euteleostomi_PTN000341960 participates in ubiquitin-dependent SMAD protein catabolic process (GO:0030579) 
20150930: Euteleostomi_PTN000341960 participates in positive regulation of transcription, DNA-templated (GO:0045893) 
20150930: Euteleostomi_PTN000341960 participates in positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511) 
20150930: Euteleostomi_PTN000342010 participates in positive regulation of BMP signaling pathway (GO:0030513) 
20150930: Euteleostomi_PTN000342010 participates in motor neuron axon guidance (GO:0008045) 
20150930: Eukaryota_PTN000967687 participates in endoplasmic reticulum unfolded protein response (GO:0030968) 
20150930: Eukaryota_PTN000967687 participates in ER-associated ubiquitin-dependent protein catabolic process (GO:0030433) 
20150930: node_PTN001864393 participates in root development (GO:0048364) 
20150930: node_PTN001864393 participates in cell division (GO:0051301) 
20150930: Pentapetalae_PTN001864405 participates in positive regulation of abscisic acid-activated signaling pathway (GO:0009789) 
20150930: Opisthokonta_PTN001102294 participates in negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).