# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 17 Mar 2016: Updated by: TOUCHUP-v1.14 26 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20151023: Eukaryota_PTN000488224 has function nucleocytoplasmic transporter activity (GO:0005487) 20151023: Eukaryota_PTN000488224 has function phospholipid binding (GO:0005543) 20151023: Eukaryota_PTN000488224 has function single-stranded DNA binding (GO:0003697) # cellular_component 20151023: Eukaryota_PTN000488224 is found in nuclear pore central transport channel (GO:0044613) 20151023: Eukaryota_PTN000488224 is found in nuclear pore nuclear basket (GO:0044615) # biological_process 20151023: Eukaryota_PTN000488224 participates in NLS-bearing protein import into nucleus (GO:0006607) 20151023: Eukaryota_PTN000488224 participates in nuclear pore organization (GO:0006999) 20151023: Eukaryota_PTN000488224 participates in regulation of transcription, DNA-templated (GO:0006355) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES THis family contains the NUP35 (vertebrate nomenclature) of the nuclear pore complex (NPC). In S. cerevisiae, there is a duplication; both NUP53 and NUP59 (aka ASM4) are considered equivalent to vertebrate NUP35. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).