# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150817: Chordata_PTN001085373 has function cytokine activity (GO:0005125) # cellular_component 20150817: Chordata_PTN001085373 is found in extracellular region (GO:0005576) 20150817: Tetrapoda_PTN000482584 is found in CRLF-CLCF1 complex (GO:0097058) 20150817: Tetrapoda_PTN000482584 is found in CNTFR-CLCF1 complex (GO:0097059) # biological_process 20150817: Chordata_PTN001085373 participates in cell surface receptor signaling pathway (GO:0007166) 20150817: Tetrapoda_PTN000482584 participates in positive regulation of B cell proliferation (GO:0030890) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).