# HISTORY 13 Jan 2017: Saved by pgaudet using Paint v2.29 on 13 Jan 2017 using PANTHER version UPL 11.0 # molecular_function # cellular_component 20170113: Deuterostomia_PTN000482345 is found in integral component of plasma membrane (GO:0005887) 20170113: root_PTN000482304 is found in integral component of membrane (GO:0016021) # biological_process # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).