# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 16 Mar 2016: Updated by: TOUCHUP-v1.14 26 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20151009: root_PTN001848130 has function serine-type endopeptidase inhibitor activity (GO:0004867) # cellular_component 20151009: Amniota_PTN000752109 is found in extracellular space (GO:0005615) 20151009: Amniota_PTN000752109 is found in acrosomal vesicle (GO:0001669) # biological_process 20151009: root_PTN001848130 participates in negative regulation of serine-type endopeptidase activity (GO:1900004) 20151009: Amniota_PTN000752109 participates in regulation of acrosome reaction (GO:0060046) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).