# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150805: root_PTN000479179 has function oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627) 20150805: Eukaryota_PTN001847198 has function sterol delta7 reductase activity (GO:0009918) 20150805: Eukaryota_PTN000479182 has function delta24(24-1) sterol reductase activity (GO:0000246) 20150805: Opisthokonta_PTN001082975 has function 7-dehydrocholesterol reductase activity (GO:0047598) 20150805: Fungi_PTN001083003 has function delta14-sterol reductase activity (GO:0050613) 20150805: Viridiplantae_PTN000479315 has function delta14-sterol reductase activity (GO:0050613) # cellular_component 20150805: root_PTN000479179 is found in integral component of endoplasmic reticulum membrane (GO:0030176) 20150805: Opisthokonta_PTN001082983 is found in nuclear inner membrane (GO:0005637) 20150805: Euteleostomi_PTN000479246 is found in integral component of nuclear inner membrane (GO:0005639) 20150805: Euteleostomi_PTN000479271 is NOT found in nuclear inner membrane (GO:0005637) 20150805: Euteleostomi_PTN000479246 is NOT found in integral component of endoplasmic reticulum membrane (GO:0030176) # biological_process 20150805: root_PTN000479179 participates in sterol biosynthetic process (GO:0016126) 20150805: Eukaryota_PTN001847198 participates in brassinosteroid biosynthetic process (GO:0016132) 20150805: Eukaryota_PTN000479182 participates in ergosterol biosynthetic process (GO:0006696) 20150805: Opisthokonta_PTN001082975 participates in cholesterol biosynthetic process (GO:0006695) 20150805: Fungi_PTN001083003 participates in ergosterol biosynthetic process (GO:0006696) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).