# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
16 Mar 2016: Updated by: TOUCHUP-v1.14
26 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20160129: cellular organisms_PTN000474664 has function structural constituent of ribosome (GO:0003735) 
20160130: cellular organisms_PTN000474664 has function large ribosomal subunit rRNA binding (GO:0070180) 
20160129: Eukaryota_PTN000474938 has function protein kinase activator activity (GO:0030295) 
20160129: Eukaryota_PTN000474869 has LOST/MODIFIED function structural constituent of ribosome (GO:0003735) 

# cellular_component
20160129: cellular organisms_PTN000474664 is found in preribosome, large subunit precursor (GO:0030687) 
20160129: cellular organisms_PTN000474664 is found in cytosolic large ribosomal subunit (GO:0022625) 
20160130: Eukaryota_PTN000474869 is found in nucleolus (GO:0005730) 
20160129: Eukaryota_PTN000474869 is NOT found in cytosolic large ribosomal subunit (GO:0022625) 

# biological_process
20160129: cellular organisms_PTN000474664 participates in cytoplasmic translation (GO:0002181) 
20160129: Eukaryota_PTN000474938 participates in positive regulation of protein kinase activity (GO:0045860) 
20160130: Eukaryota_PTN000474869 participates in rRNA processing (GO:0006364) 
20160130: Eukaryota_PTN000474869 participates in ribosomal large subunit assembly (GO:0000027) 
20160130: Eukaryota_PTN000474869 participates in nuclear-transcribed mRNA catabolic process (GO:0000956) 
20160129: Eukaryota_PTN000474869 does NOT participate in cytoplasmic translation (GO:0002181) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
This family is primarily large ribosomal subunits of the stalk region. However, one clade (MRT4) has diverged and is involved in large subunit biogenesis, but is not part of the ribosome.
Archaea-Eukaryota_PTN000474664
- PTN001844891 (duplication node)
-- Archaea_PTN000475062 (rpl10)
-- Archaea_PTN001080201 (rpl10 & rpl12)
- PTN000474665 (duplication node)
-- Eukaryota_PTN000474782 (Sc RPP0, vert RPLP0
-- Eukaryota_PTN000474938 (Sc RPP1B & RPP1A, vert RPLP1)
-- Eukaryota_PTN000474869 (Sc MRT4, vert MRTO4)
-- Eukaryota_PTN001845013 (plant sequences - small node)
-- Eukaryota_PTN001845031 (4 sequences: 1 Dicty, 1 Trypanosoma, 2 Leishmania)
-- Eukaryota_PTN000474666 (Sc RPP2A & RPP2B, vert RPLP2)

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).