# HISTORY
26 Mar 2016: Updated by: TOUCHUP-v1.15
16 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function

# cellular_component
20150121: Eukaryota_PTN000470005 is found in membrane (GO:0016020) 
20150121: Eukaryota_PTN000470005 is found in cilium (GO:0005929) 
20150121: Eukaryota_PTN000470005 is found in BBSome (GO:0034464) 

# biological_process
20150121: Eukaryota_PTN000470005 participates in cilium assembly (GO:0042384) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
This family contains the BBS9 subunit of the highly conserved seven-member BBSome complex, a membrane coat complex that traffics membrane proteins to the primary cilium (PMID:19575670, PMID:20697559, PMID:20603001). Whether this trafficking occurs by a vesicular mechanism or as a planar patch that moves laterally within the membrane is not yet clear as of August 2014. The BBSome also appears to be an adaptor for some retrograde intraflagellar traffic (IFT) within the cilium (PMID:20697559).
Comments on the tree & sequences
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This tree looks very straightforward. All six duplication nodes look like sequence issues rather than true duplications:
- From the pig, Sus scrofa, both sequences look partial with  I3LAV0_PIG comprising the N-terminal portion and F1SIK4_PIG (the named BBS9 sequence) comprising the C-terminal portion (with perhaps a small gap between the two).
- From Monodelphis domestica (Gray short-tailed opossum), both sequences, K7E5G6_MONDO and F7DMU6_MONDO, look partial with the latter being the better of the two.
- From Ornithorhynchus anatinus (Duckbill platypus), the sequence K7EDV2_ORNAN appears to be a fragment, while F6Z899_ORNAN looks complete, or nearly complete.
- From Strongylocentrotus purpuratus, all three sequences (H3J7V6_STRPU, H3IFG0_STRPU, and H3HFV5_STRPU) are obsolete. The first two are partial, while the third appears complete.
- From Daphnia pulex (Water flea), both sequences (E9G2T4_DAPPU and E9G2T5_DAPPU) appear partial.
- From Nematostella vectensis (Starlet sea anemone), the A7STA0_NEMVE appears complete, or at least mostly complete. The other three sequences (A7T3G7_NEMVE, A7T3G6_NEMVE, and A7T937_NEMVE) are partial, with the third of them containing a longer C-terminus than the full length A7STA0_NEMVE.
Also:
- The sole rat sequence F1M285_RAT looks like a partial sequence.
Comments on annotations and propagations
-----------------------------------
- I did not propagate a large number of BP annotations based on developmental phenotypes because they are all downstream of the primary defect in trafficking to the cilium and the resulting defect in cilary function.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).