# HISTORY 12 Oct 2016: Saved by mfeuerma using Paint 2.22 # molecular_function 20161012: root_PTN000468650 has function dihydropteroate synthase activity (GO:0004156) 20161012: Actinomycetales_PTN001076083 has LOST/MODIFIED function dihydropteroate synthase activity (GO:0004156) # cellular_component 20161012: Bacteria _PTN000468680 is found in cytosol (GO:0005829) 20161012: Eukaryota_PTN000468652 is found in mitochondrial envelope (GO:0005740) 20161012: Viridiplantae_PTN000468665 is NOT found in mitochondrial envelope (GO:0005740) # biological_process 20161012: root_PTN000468650 participates in tetrahydrofolate biosynthetic process (GO:0046654) 20161012: Actinomycetales_PTN001076083 does NOT participate in tetrahydrofolate biosynthetic process (GO:0046654) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).