# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140730: node_PTN000466212 has function cytokine receptor activity (GO:0004896) 20140730: Amniota_PTN000466418 has function interleukin-10 receptor activity (GO:0004920) 20140730: Tetrapoda_PTN001074511 has function interleukin-10 receptor activity (GO:0004920) 20140730: Euteleostomi_PTN000751601 has function interleukin-20 binding (GO:0042015) 20140730: Amniota_PTN000466380 has function type I interferon receptor activity (GO:0004905) 20140730: Amniota_PTN001074542 has function interleukin-22 receptor activity (GO:0042018) # cellular_component 20140730: node_PTN000466212 is found in plasma membrane (GO:0005886) 20140730: node_PTN000466212 is found in integral component of membrane (GO:0016021) # biological_process 20140730: node_PTN000466212 participates in cytokine-mediated signaling pathway (GO:0019221) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).